The present study was conducted to study the protective effects of zinc suiphate (ZnS),
nicotinic acid (NA) and Nigella sativa on the alcohol induced gastric lesion in male
albino rats. The study was carried out on (48) adult male albino rats weighing 200-250 gms. The rats were divided into two equal groups, then. Each group was
subdivided into four equal subgroups. Group (A): The normal rats which are
subdivided into: subgroup (l): control group subgroup (2): the rats were
intraperitoneally injected by zinc sulphate subgroup (3) the rats were
intraperitoneally injected by nicotinic acid and subgroup (4) the rats were orally
administrated Nigella Sativa oil daily for two weeks. Group (B) The rats were
subdivided into: subgroup (l): rats were administrated ethanol 40% orally for two
weeks, subgroup; (2): the rats were administrated ethanol 40% orally and
intraperitoneally injected by zinc sulphate, subgroup (3) the rats were administrated
ethanol 40% oral!y and intraperitoneally injected by nicotinic acid and subgroup (4)
the rats were administrated by ethanol 40% orally with Nigella Sativa oil orally daily
for two weeks. After the last dose of eachgroup, the animals were left for one hour
then anaesthetized by ether. The gastric secretion was collected in the acute rat
fistula. The abdomen was incised and both the stomach and the duodenum were
exposed. The gastric secretion was collected for the analysis and sections were taken
for histological examination. The results showed significant increase of gastric mucin
content, and glutathione and significant decrease in the volume of the gastric
secretion, peptic activity, free acidity and gastric histamine content in ethanol
induced gastric lesion with either zinc sulphate, nicotinic acid and Nigella Sativa oil.
histopathological picture showed improvement of hemorrhage, edema and increase in
the mucus layer thickness and regeneration of the gastric mucosal erosion. It is
recommended to increase the administration of zinc sulphate, nicolinic acid and
Nigella Sativa to patients with gastric ulcer.