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34791

Effect of Erythropoietin on Some aspects of Carbohydrate and Lipid metabolism in Obese and diabetic rats

Article

Last updated: 03 Jan 2025

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Tags

Endocrine and Reproductive Physiology

Abstract

Objectives : To study effect of erythropoietin (EPO) on some aspects of carbohydrate and lipid metabolism in obese and diabetic rats. Material and methods. This study was carried on (50) albino female rats; divided into 5 groups, each consisted of 10 rats: Control, obese, diabetic, erythropoietin treated obese group (after induction of obesity it was injected by erythropoietin 600u/kg I.P. once daily every other day for 5 weeks) and erythropoietin treated diabetic group (after induction of diabetes it was treated as previous group). At the end of experimental period serum samples were collected for estimation of: fasting serum glucose, serum insulin, insulin resistance (HOMA IR), insulin sensitivity (HOMA S%), serum LDL, serum HDL, serum triglyceride (TG), serum cholesterol, glycosylated Hb% and measurement of body mass Index (BMI) Results: Erythropoietin treated obese group showed significant decrease in fasting glucose, insulin, HOMA IR, serum LDL, TG, cholesterol and BMI. While, serum HDL and HOMA S% were significantly increased when these results were compared to obese group. Erythropoietin treated diabetic group produced insignificant change in all studied parameters with exception of significant decrease in fasting glucose, TG and glycosylated Hb% when these results compared to diabetic group. Conclusion: EPO can be considered as adjunct anti-diabetic/obesity drug to reduce blood glucose, hypolipidemic effect and attenuate weight gain.

DOI

10.21608/besps.2014.34791

Keywords

erythropoietin, diabetes, Obesity, HOMA-I/R, HOMA S %

Authors

First Name

Rizk

Last Name

EL Kholy

MiddleName

-

Affiliation

Physiology Department, Faculty of Medicine, Tanta University

Email

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City

-

Orcid

-

First Name

Ghada

Last Name

Abo Fard

MiddleName

-

Affiliation

Physiology Department, Faculty of Medicine, Tanta University

Email

-

City

-

Orcid

-

First Name

Abeer

Last Name

Abo Zeid

MiddleName

-

Affiliation

Physiology Department, Faculty of Medicine, Tanta University

Email

abeer.abozeid2@yahoo.com

City

-

Orcid

-

First Name

Marwa

Last Name

Awad

MiddleName

-

Affiliation

Physiology Department, Faculty of Medicine, Tanta University

Email

-

City

-

Orcid

-

Volume

34

Article Issue

2

Related Issue

5687

Issue Date

2014-12-01

Receive Date

2014-08-12

Publish Date

2014-12-01

Page Start

176

Page End

186

Print ISSN

1110-0842

Online ISSN

2356-9514

Article File

BESPS_Volume 34_Issue 2_Pages 176-186.pdf

PDF . 759.3kB

Link

https://besps.journals.ekb.eg/article_34791.html

Detail API

https://besps.journals.ekb.eg/service?article_code=34791

Order

3

Type

Original Article

Type Code

567

Publication Type

Journal

Publication Title

Bulletin of Egyptian Society for Physiological Sciences

Publication Link

https://besps.journals.ekb.eg/

MainTitle

Effect of Erythropoietin on Some aspects of Carbohydrate and Lipid metabolism in Obese and diabetic rats

Details

Type

Article

Created At

22 Jan 2023