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34790

Uterine Reactivity During The Estrous Cycle Phase of Experimentally-Induced Hyperurecemic Rats

Article

Last updated: 03 Jan 2025

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Subjects

-

Tags

Endocrine and Reproductive Physiology

Abstract

Hyperuricemia is considered as an important risk factor of miscarriage and prematurity. This study aims to demonstrate if there is a direct effect of hyperuricemia on the spontaneous uterine contractions or uterine reactivity. Hyperuricemia was induced by 4 weeks of daily intraperitoneal (i.p.) injection of oxonic acid potassium salt (250mg/kg) in a group of 10 rats. Another group (10 rats) received oxonic acid potassium salt and allopurinol (150 mg/L drinking water) daily for 4 weeks. A control group (10 rats) was injected daily by 0.9% saline solution i.p. for 4 weeks. At the end of the experiment, systolic blood pressure was measured and serum uric acid (UA), serum urea, serum creatinine, serum malondialdehyde (MDA) and erythrocyte superoxide dismutase (SOD) activity were estimated. The uterine horns were taken for recording their reactivity to oxytocin and Ach. The data showed that hyperuricemia significantly increased serum UA, plasma MDA and systolic blood pressure and significantly decrease SOD activity, but insignificantly changed serum urea and creatinine and unexpectedly insignificantly changed the spontaneous uterine contractions and uterine reactivity to either of acetylcholine or oxytocin. Allopurinol treatment significantly decreased serum UA, plasma MDA and systolic blood pressure but insignificantly changed serum urea & creatinine, SOD activity, spontaneous uterine contractions and the uterine reactivity to either of Ach or oxytocin

DOI

10.21608/besps.2014.34790

Keywords

Uterine reactivity, Hyperuricemia, Estrous cycle, Oxonic acid, Rats

Authors

First Name

Heba

Last Name

Salem

MiddleName

-

Affiliation

Medical Physiology Department, Faculty of Medicine, Menofia University

Email

-

City

-

Orcid

-

First Name

Suzy

Last Name

Ewida

MiddleName

-

Affiliation

Medical Physiology Department, Faculty of Medicine, Menofia University

Email

-

City

-

Orcid

-

First Name

Sally

Last Name

Donia

MiddleName

-

Affiliation

Medical Physiology Department, Faculty of Medicine, Menofia University

Email

-

City

-

Orcid

-

Volume

34

Article Issue

2

Related Issue

5687

Issue Date

2014-12-01

Receive Date

2014-05-01

Publish Date

2014-12-01

Page Start

148

Page End

159

Print ISSN

1110-0842

Online ISSN

2356-9514

Article File

BESPS_Volume 34_Issue 2_Pages 148-159.pdf

PDF . 712.5kB

Link

https://besps.journals.ekb.eg/article_34790.html

Detail API

https://besps.journals.ekb.eg/service?article_code=34790

Order

1

Type

Original Article

Type Code

567

Publication Type

Journal

Publication Title

Bulletin of Egyptian Society for Physiological Sciences

Publication Link

https://besps.journals.ekb.eg/

MainTitle

Uterine Reactivity During The Estrous Cycle Phase of Experimentally-Induced Hyperurecemic Rats

Details

Type

Article

Created At

22 Jan 2023