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34417

The effect of heparin on cerulein - induced pancreaities in albino rats

Article

Last updated: 24 Dec 2024

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Tags

GIT Physiology

Abstract

The present work aimed to investigate the effect of heparin on cerulein–induced acute pancreatitis model in albino rats. Methods: Thirty male albino rats were used in the study. They were divided into 3 groups: Control group, AP (Acute pancreatitis) group, and heparin–treated group. AP was induced by subcutaneous injection of cerulein (20μg/kg) four times at one hour intervals. At the end of experiment, the animals were sacrificed and blood samples were collected for determination of plasma amylase, lipase levels, tumor necrosis factor–alpha (TNF-α), interleukin-6 (IL-6), APTT (Activated partial thromboplastin time). Hematocrit levels were measured. Pancreatic tissue was evaluated histopathologically. Results: Compared with control group, plasma amylase, lipase, TNF-α, IL-6 and hematocrit levels in AP group were significantly increased (P<0.05). After heparin treatment, plasma amylase, lipase, TNF-α, IL-6 and hematocrit levels were significantly decreased (P<0.05). APTT was significantly prolonged in AP group as compared to control group, but was significantly decreased after heparin treatment. Conclusions: Treatment with heparin improved the biochemical and histopathological findings in a rat model of experimental pancreatitis. Although, our findings suggest that heparin might be considered an effective agent for the treatment of acute pancreatitis, this notion should be supported with further clinical investigations

DOI

10.21608/besps.2014.34417

Keywords

Acute pancreatitis, Cerulein, Heparin, Interleukin-6, Activated partial thromboplastin time

Authors

First Name

Nermin

Last Name

Madi

MiddleName

-

Affiliation

Medical Physiology Department, Faculty of Medicine, Tanta University, El-Gharbia, Egypt

Email

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City

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Orcid

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First Name

Mervat

Last Name

El-Saka

MiddleName

-

Affiliation

Medical Physiology Department, Faculty of Medicine, Tanta University, El-Gharbia, Egypt

Email

-

City

-

Orcid

-

Volume

34

Article Issue

1

Related Issue

5686

Issue Date

2014-06-01

Receive Date

2014-04-27

Publish Date

2014-06-01

Page Start

135

Page End

147

Print ISSN

1110-0842

Online ISSN

2356-9514

Article File

BESPS_Volume 34_Issue 1_Pages 135-147.pdf

PDF . 847.2kB

Link

https://besps.journals.ekb.eg/article_34417.html

Detail API

https://besps.journals.ekb.eg/service?article_code=34417

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Type

Original Article

Type Code

567

Publication Type

Journal

Publication Title

Bulletin of Egyptian Society for Physiological Sciences

Publication Link

https://besps.journals.ekb.eg/

MainTitle

The effect of heparin on cerulein - induced pancreaities in albino rats

Details

Type

Article

Created At

22 Jan 2023