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34414

Role of melatonin on immobilization induced effects in rat soleus muscle

Article

Last updated: 03 Jan 2025

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Tags

Muscle Physiology

Abstract

Objectives: Immobilization results in dramatic losses of skeletal muscle mass. Several reports have strongly implicated oxidative stress as partially causative of disuse atrophy. So, the aim of this study was to investigate the deleterious effects of immobilization upon rat skeletal muscle and to detect the possible protective role of melatonin on these effects. Methods: male Wister albino rats were subjected to immobilization procedure, then divided into (C) control group, and three treated groups with melatonin either once daily at morning (M1) group or at night (M2) group or twice daily (M3) group. Soleus muscle was used to detect myosin heavy chain (MHC) distribution, gene expression and histological examination. Results: The study demonstrated that treatment with melatonin once at night and twice per day prevented the deleterious effects of immobilization by increasing the total antioxidant capacity, decreasing the muscle atrophy F-box (MAFbx) and muscle-specific RING finger-1 (MuRF-1) and increasing in insulin-like growth factor 1 receptors (IGF-1R) gene expression. Conclusions: The results of this study provide evidence that melatonin administration reduces the deleterious effects of immobilization on skeletal muscle. SO, exogenous melatonin may be a possible candidate for hormonal therapy in immobilization-induced muscle atrophy.

DOI

10.21608/besps.2014.34414

Authors

First Name

Abeer

Last Name

Mostafa

MiddleName

-

Affiliation

Medical Physiology Department, Mansoura Faculty of Medicine, Egypt

Email

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City

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Orcid

-

First Name

Shereen

Last Name

Samir

MiddleName

-

Affiliation

Medical Physiology Department, Mansoura Faculty of Medicine, Egypt

Email

-

City

-

Orcid

-

Volume

34

Article Issue

1

Related Issue

5686

Issue Date

2014-06-01

Receive Date

2014-04-11

Publish Date

2014-06-01

Page Start

104

Page End

120

Print ISSN

1110-0842

Online ISSN

2356-9514

Article File

BESPS_Volume 34_Issue 1_Pages 104-120.pdf

PDF . 677.0kB

Link

https://besps.journals.ekb.eg/article_34414.html

Detail API

https://besps.journals.ekb.eg/service?article_code=34414

Order

8

Type

Original Article

Type Code

567

Publication Type

Journal

Publication Title

Bulletin of Egyptian Society for Physiological Sciences

Publication Link

https://besps.journals.ekb.eg/

MainTitle

Role of melatonin on immobilization induced effects in rat soleus muscle

Details

Type

Article

Created At

22 Jan 2023