Beta
ManageSearchChatDiscover
34394

Effect of systemic ghrelin administration on experimental myocardial infarction induced by isoproterenol in rats

Article

Last updated: 03 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Cardiovascular Physiology

Abstract

Objective: Is to investigate the possible effects of ghrelin administration on isoproterenol (ISO)-induced myocardial infarction (MI) in albino rats of local strain. Methods: 30 adult male albino rats were divided into 3 groups, each consisted of 10 rats. Group I: received saline as a control group. Group II: ISO injected subcutaneously to rats (100 mg/kg) at an interval of 24 h for 2 days. Group III: rats were pretreated with ghrelin (150 μg/kg, s.c.) for 15 days and at the 14th and 15th days received ISO as in group II. Levels of serum cardiac enzymes (CK, CK-MB fraction and LDH), lipid profiles and plasma TNF-α and IL-6 were evaluated. Specimens from heart were obtained to measure the levels of TNF-α, IL-6, lipid peroxidation products (MDA,GSH)and endogenous antioxidants enzymes activities (CAT,SOD,PON1). Results: ISO- treated rats showed significant increase in the activities of serum cardiac enzymes, plasma and cardiac tissues TNF-α and IL-6, as well as in heart tissues level of MDA and GSH and in serum cholesterol, triglycerides, LDL-cholesterol, VLDL .On the other hand there are significant decrease in tissues SOD and PON1 enzyme activities and serum HDL-cholesterol when these results were compared to control rats. Pretreatment with ghrelin significantly attenuated these changes as compared to ISO treated rats (group I). Conclusions: This finding demonstrated that ghrelin may be considered as promising new therapies for MI.

DOI

10.21608/besps.2014.34394

Keywords

Isoproterenol, myocardial infarction, Creatine kinase-MB, Paraoxonase

Authors

First Name

Abeer

Last Name

Abozeid

MiddleName

-

Affiliation

Department of Physiology, Biochemistry ,Faculty of Medicine, Tanta University, Tanta, Egypt

Email

-

City

-

Orcid

-

First Name

Ghada

Last Name

Abou Fard

MiddleName

-

Affiliation

Departments of Physiology, Faculty of Medicine, Tanta University, Tanta, Egypt

Email

-

City

-

Orcid

-

First Name

Noha

Last Name

Shafik

MiddleName

-

Affiliation

Department of Biochemistry,Faculty of Medicine, Tanta University, Tanta, Egypt

Email

-

City

-

Orcid

-

Volume

34

Article Issue

1

Related Issue

5686

Issue Date

2014-06-01

Receive Date

2014-02-10

Publish Date

2014-06-01

Page Start

43

Page End

56

Print ISSN

1110-0842

Online ISSN

2356-9514

Article File

BESPS_Volume 34_Issue 1_Pages 43-56.pdf

PDF . 775.7kB

Link

https://besps.journals.ekb.eg/article_34394.html

Detail API

https://besps.journals.ekb.eg/service?article_code=34394

Order

4

Type

Original Article

Type Code

567

Publication Type

Journal

Publication Title

Bulletin of Egyptian Society for Physiological Sciences

Publication Link

https://besps.journals.ekb.eg/

MainTitle

Effect of systemic ghrelin administration on experimental myocardial infarction induced by isoproterenol in rats

Details

Type

Article

Created At

22 Jan 2023