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34020

The effect of resveratrol on insulin resistance, metabolic syndrome and hepatic oxidative stress in fructose- fed rats

Article

Last updated: 03 Jan 2025

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Tags

Physiology of Nutrition and metabolism

Abstract

Mtabolic syndrome and oxidative stress are common complications of type 2 diabetes mellitus. The aim of this work was to study the effect of resveratrol, a widely used nutritional supplement on insulin sensitivity, some metabolic parameters and hepatic oxidative stress in high fructose- fed rats. Material & methods: Male Wister rats (180-200g) were divided into 3 groups 10 per each. G1: Control group was fed 65% corn starch diet. G2: Fructose-fed insulin resistant group (HFD) was fed 65% fructose diet. G3: (HFD + Resveratrol) was fed with 65% fructose along with a single dose of 10 mg/kg/day of resveratrol orally through intra gastric tube for a period of 8 weeks. Results: At the end of the feeding schedule, HFD group had significant hyperglycemia, hyperinsulinemia and insulin resistance as evident by HOMA IR. There were significant increase in triglyceride and nitric oxide levels as well as in hepatic ThioBabituric Acid Reactive Substance (TBARS) and significant decrease in vitamin C in HFD group compared with control group. Administration of resveratrol significantly improved the altered metabolic parameters, hepatic oxidative stress parameters and significantly reduced inflammatory markers (Monocyte Chemoattractant Protein -1(MCP-1), Tumor Necrosis Factora (TNFa) and Regulated on Activation Normal T cells Expressed and Secreted (RANTES). 
Conclusion: Resveratrol supplementation might attenuate the insulin resistance, hepatic oxidative stress state and inflammatory state in metabolic syndrome

DOI

10.21608/besps.2014.34020

Keywords

Resveratrol, High fructose diet, Metabolic syndrome, Hepatic oxidative stress

Authors

First Name

Ahmed

Last Name

Abdalfattah

MiddleName

-

Affiliation

Department of Physiology, Faculty of Medicine, Tanta University, Egypt

Email

pacemaker107@gmail.com

City

-

Orcid

-

Volume

34

Article Issue

1

Related Issue

5686

Issue Date

2014-06-01

Receive Date

2014-02-10

Publish Date

2014-06-01

Page Start

27

Page End

42

Print ISSN

1110-0842

Online ISSN

2356-9514

Article File

BESPS_Volume 34_Issue 1_Pages 27-42.pdf

PDF . 891.8kB

Link

https://besps.journals.ekb.eg/article_34020.html

Detail API

https://besps.journals.ekb.eg/service?article_code=34020

Order

3

Type

Original Article

Type Code

567

Publication Type

Journal

Publication Title

Bulletin of Egyptian Society for Physiological Sciences

Publication Link

https://besps.journals.ekb.eg/

MainTitle

The effect of resveratrol on insulin resistance, metabolic syndrome and hepatic oxidative stress in fructose- fed rats

Details

Type

Article

Created At

22 Jan 2023