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34478

The potential protective effects of tetrahydrobiopterin on cadmium-induced pancreatic changes in male rats

Article

Last updated: 03 Jan 2025

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Tags

GIT Physiology

Abstract

Cadmium (Cd) is a widespread environmental and industrial pollutant. It accumulates in the pancreas and could influence its endocrine and exocrine functions. Tetrahydrobiopterin (BH4) is essential for various processes, and present in all tissues of higher organisms. This study was designed to investigate the effect of BH4 on the acute pancreatic damage induced by Cd and detect its mechanism(s) of action. Thirty rats were randomly divided into three groups (10 rats each). Control : received saline, Cd: received (single dose of CdCl2 4 mg/kg, i.p.) and BH4+Cd : received (single dose of BH4 20 mg/kg, i.p.) one hour before single dose of CdCl2 (4 mg/kg, i.p.). The α-amylase, lipase, glucose, insulin and interleukin 6 (IL-6) levels were measured in serum and intercellular adhesion molecule-1(ICAM-1), malondialdehyde (MDA) and superoxide dismutase (SOD) levels were measured in pancreatic homogenate. Histopathological examination of pancreas was done. BH4 improved pancreatic functions, where α-amylase, lipase, glucose and IL-6 levels were significantly decreased while insulin levels were significantly increased in serum. Pancreatic damage was ameliorated as evident by significant decrease of ICAM-1 and MDA and significant increase of SOD levels in pancreatic homogenate. Also, the disturbed pancreatic tissues were ameliorated. In conclusion, BH4 induced improvements in pancreatic tissue and functions in cadmium-exposed rats. Part of BH4 beneficial effects could be attributed to anti-oxidative and anti-inflammatory activity

DOI

10.21608/besps.2015.34478

Keywords

Tetrahydrobiopterin, cadmium, Inflammation, Oxidative Stress

Authors

First Name

Ebtihal

Last Name

Abd EL-Aziz

MiddleName

-

Affiliation

Department of Physiology. Faculty of Medicine. Assiut University. Egypt.

Email

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City

-

Orcid

-

First Name

Nashwa

Last Name

Abd El-Mottaleb

MiddleName

-

Affiliation

Department of Physiology. Faculty of Medicine. Assiut University. Egypt.

Email

nashwa_ali1@hotmail.com

City

-

Orcid

-

Volume

35

Article Issue

2

Related Issue

5120

Issue Date

2015-12-01

Receive Date

2015-10-15

Publish Date

2015-12-01

Page Start

73

Page End

85

Print ISSN

1110-0842

Online ISSN

2356-9514

Article File

BESPS_Volume 35_Issue 2_Pages 73-85.pdf

PDF . 1.3MB

Link

https://besps.journals.ekb.eg/article_34478.html

Detail API

https://besps.journals.ekb.eg/service?article_code=34478

Order

3

Type

Original Article

Type Code

567

Publication Type

Journal

Publication Title

Bulletin of Egyptian Society for Physiological Sciences

Publication Link

https://besps.journals.ekb.eg/

MainTitle

The potential protective effects of tetrahydrobiopterin on cadmium-induced pancreatic changes in male rats

Details

Type

Article

Created At

22 Jan 2023