Objectives: Stress of various patterns has been linked to pathologies of body organs, including gastric mucosal damage. The polyphenol Resveratrol (RES) has been reported to have anti-ulcer properties against some models of gastric ulcer. However, its effect against experimental chronic unpredictable stress (CUS)-induced ulcer per se was not studied before. This study aims to investigate the gastric mucosal damage induced by CUS, its potential prevention by RES, and the mechanisms of action implicated. Methods. Thirty two rats were randomized into 4 groups, 8 rats each: Control, Control+ RES, CUS, and CUS+RES. The CUS was applied for 3 weeks, during which the vehicle (Normal Saline) or RES (25 mg.kg-1) was intraperitoneally administered on daily doses. Ulceration index, oxidative, inflammatory and apoptotic parameters were measured. Results. CUS induced severe gastric lesions of various extents, with considerable erosive microscopic features. There was significant increase in the levels of TBARS, TNF-α, IL-6, Bax and caspase-3 with concomitant significant decrease in the levels of SOD, GPX, PGE2, and Bcl-2 in CUS rats compared to control rats. Resveratrol treatment to CUS stressed rats brought all of these parameters to control levels, and remarkably maintained the normal morphology and microscopic architectures of gastric tissue. Conclusion. The present data show that supplementation with resveratrol ameliorates CUS-induced gastric lesions via its antioxidant, anti-inflammatory and anti-apoptotic potentials; a promising protective consequence that may demand further exploration.