8648

Association of interleukin-1 receptor antagonist (IL1RN) genetic variants with severity of knee osteoarthritis

Article

Last updated: 03 Jan 2025

Subjects

-

Tags

Physiological Genomics

Abstract

Osteoarthritis (OA) is a chronic musculoskeletal disorder, characterized by degeneration of articular cartilage and decreased motion range of affected joints. It is regarded as the most common cause of disability among elderly population worldwide. This study aimed to detect interleukin-1 receptor antagonist (IL1RN) genotypes at single nucleotide polymorphism (SNP) rs9005 and rs315943, in patients with knee osteoarthritis, and to clarify their influence on susceptibility and severity of the osteoarthritic disease. Forty-seven unrelated Egyptian patients with primary knee OA and thirty-six control subjects, with matched age, sex and body mass index were included in this study. All patients were subjected to full history taking, general examination and complete knee and joint examination including assessment of the severity of knee OA clinically using the Lequesne'salgofunctional Index and radiological grading by the Kellgren-Lawrence(KL) grade scale. Genotyping assays of IL1RN at SNP rs9005 and rs315943 were performed using real time PCR. IL1RN rs9005 AG, GG genotypes, G allele, as well as rs9005- rs315943 GC haplotype were associated with risk of OA development, while AChaplotype was associated with protective effect against OA development. Younger age of disease onset was associated with rs9005 GG genotype. Higher pain, maximum distance walked, activities of daily living (ADL), Lequesne's scores and KL grading were associated with rs9005 GG, rs315943 CC genotypes and GC haplotype. Whereas, lower pain, maximum distance walked, ADL, Lequesne's scores and KL grading were associated with rs9005 AA, rs315943 TT and AT haplotype.

DOI

10.21608/besps.2016.8648

Keywords

Interleukin-1 receptor antagonist gene, Knee osteoarthritis, SNP

Authors

First Name

Inas

Last Name

Ahmed

MiddleName

A.

Affiliation

Department of Medical Biochemistry, Molecular Biology and Biotechnology Unit, Faculty of Medicine, Benha University, Al Qalyubia, Egypt

Email

inas.ahmed@fmed.bu.edu.eg

City

-

Orcid

-

First Name

Amira

Last Name

Mansour

MiddleName

-

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Benha University, Egypt.

Email

-

City

-

Orcid

-

First Name

Basant

Last Name

Elnady

MiddleName

M.

Affiliation

Department of Rheumatology & Rehabilitation and Physical Medicine, Faculty of Medicine, Benha University, Egypt.

Email

-

City

-

Orcid

-

First Name

Shaza

Last Name

Abdul Basset

MiddleName

A.

Affiliation

Department of Rheumatology & Rehabilitation and Physical Medicine, Faculty of Medicine, Benha University, Egypt.

Email

-

City

-

Orcid

-

First Name

Iman

Last Name

Fawzy

MiddleName

Mohammad

Affiliation

Laboratory Medicine Department, Mansoura Fever Hospital, Mansoura, Egypt.

Email

-

City

-

Orcid

-

Volume

36

Article Issue

2

Related Issue

1656

Issue Date

2016-12-01

Receive Date

2018-07-04

Publish Date

2016-12-01

Page Start

85

Page End

93

Print ISSN

1110-0842

Online ISSN

2356-9514

Link

https://besps.journals.ekb.eg/article_8648.html

Detail API

https://besps.journals.ekb.eg/service?article_code=8648

Order

3

Type

Original Article

Type Code

567

Publication Type

Journal

Publication Title

Bulletin of Egyptian Society for Physiological Sciences

Publication Link

https://besps.journals.ekb.eg/

MainTitle

Association of interleukin-1 receptor antagonist (IL1RN) genetic variants with severity of knee osteoarthritis

Details

Type

Article

Created At

22 Jan 2023