Sexual deprivation stress leads to mental or sexual disorder that can occur after exposure to relative long period of not having sexual relation. Objective: The present work was undertaken to evaluate the possible effects of sexual deprivation on bone remodeling. Materials and Methods: Forty mature adult rats (twenty males and twenty females), of local strains were chosen to be the model of this work , 120-140 gm and aged two months old . They were kept on special formulated diet and tap water was freely allowed. The rats were housed in a wire mesh cage with plastic floor. Each cage was 25 Χ 25 Χ 30 cm . All rats were housed in a laboratory room subjected to normal light dark cycle, All rats were kept for 21 days in the laboratory room at comfortable room temperature for adaption before any experimental interference and to allow a copulation between male and female before deprivation. The whole length of experiment was two months i.e. twelve estrous cycle. The rats were randomly divided into two equal groups, control group, experimental group. Experimental group were exposed to sexual deprivation for 40 days. Vaginal smear examination, was performed approximately at the same time each day over the course of study for detection of acopulatory plug or by observation of spermatozoa in the vaginal smear .Also determination of serum estrogen, progesterone, calcium, phosphorus, parathormone and alkaline phosphatase enzyme in all female rats was done at the end of experiment. Also, morphology of bone and ovary in all female rats were evaluated at the end of experiment. Results: Experimental group showed significant decreased in serum calcium, estrogen and progesterone hormones compared to control group and significant increased in serum parathormone hormone, blood phosphorous level and alkaline phosphatase enzyme compared to control group. As regard histological picture of bone, our results showed that abnormal structure of bone that consisted of discrete cortex and epiphyseal plate (cartilage). Conclusion: The female rats alleged to sexual deprivation may suffer from alteration in the metabolism of bones which may lead to pathological disease called osteoporosis.