Beta
ManageSearchChatDiscover
8106

Effect of Chronic Exercise on Irisin Plasma Level and Browning of White Adipose Tissue in Rat Models with Obesity or Type 2 Diabetes Mellitus

Article

Last updated: 03 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Objective:  To study the effect of swimming exercise training on plasma irisin level and browning of white adipose tissue in rats models with obesity or type 2 diabetes mellitus (T2DM). Methods: 60 male rats were divided into 4 groups, I) Control group, II) Exercise trained group, III) Obese group: includes 2 subgroups; subgroup A received high-fat diet and subgroup B received high-fat diet associated with daily exercise training and IV) Type 2 diabetic group: includes 2 subgroups; subgroup A and B. Both subgroups have T2DM. Subgroup B, in addition, was associated with daily exercise training after induction of T2DM. Plasma samples were analyzed for irisin, fasting insulin, fasting blood glucose and lipid profile.Levels of uncoupling protein-1 in subcutaneous abdominal adipose tissue homogenates (UCP-1 SAT) and uncoupling protein-1 in perinephric adipose tissue homogenates (UCP-1 PAT) were measured.Results: Subgroup IIIA had significantly higher irisin levels and significantly lower levels of UCP-1 SAT and UCP-1 PAT compared with group I.  Subgroup IVA had significantly lower levels of irisin, UCP-1 SAT and UCP-1 PAT compared to controls. Chronic exercise significantly increased irisin, UCP-1 SAT, and UCP-1 PAT levels in group II, subgroup IIIB and subgroup IVB.  Conclusion: Swimming exercise increases the plasma irisin level in normal, obese and type 2 diabetic rats inducing browning of white adipose tissue. Irisin is increased in obesity which may be attributed to a state of irisin resistance. T2DM is associated with lower plasma irisin levels

DOI

10.21608/besps.2018.8106

Keywords

Irisin, Browning, Obesity, Type 2 diabetes mellitus, Chronic exercise

Authors

First Name

Zeinab

Last Name

EL-Said

MiddleName

-

Affiliation

Department of Physiology, Faculty of Medicine, Mansoura University, Egypt

Email

zeinabelsaid1@gmail.com

City

-

Orcid

0000-0001-7334-1015

First Name

Gehan

Last Name

El-Wakeel

MiddleName

A.

Affiliation

Department of Physiology, Faculty of Medicine, Mansoura University, Egypt.

Email

-

City

-

Orcid

-

First Name

Amr

Last Name

Abbas

MiddleName

M.

Affiliation

Department of Physiology, Faculty of Medicine, Mansoura University, Egypt.

Email

-

City

-

Orcid

-

First Name

Omayma

Last Name

Saleh

MiddleName

M.

Affiliation

Department of Internal Medicine, Faculty of Medicine, Mansoura University, Egypt.

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Sarhan

MiddleName

E.

Affiliation

Department of Physiology, Faculty of Medicine, Mansoura University, Egypt.

Email

-

City

-

Orcid

-

Volume

38

Article Issue

1

Related Issue

1558

Issue Date

2022-01-01

Receive Date

2018-06-24

Publish Date

2022-01-01

Page Start

53

Page End

65

Print ISSN

1110-0842

Online ISSN

2356-9514

Article File

BESPS_Volume 38_Issue 1_Pages 53-65.pdf

PDF . 623.1kB

Link

https://besps.journals.ekb.eg/article_8106.html

Detail API

https://besps.journals.ekb.eg/service?article_code=8106

Order

5

Type

Original Article

Type Code

567

Publication Type

Journal

Publication Title

Bulletin of Egyptian Society for Physiological Sciences

Publication Link

https://besps.journals.ekb.eg/

MainTitle

Effect of Chronic Exercise on Irisin Plasma Level and Browning of White Adipose Tissue in Rat Models with Obesity or Type 2 Diabetes Mellitus

Details

Type

Article

Created At

22 Jan 2023