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212221

Augmentation of Carpal Arthrodesis Using Mesenchymal Stem Cells Derived Microvesicles and Cancellous Bone Graft in Dogs

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Last updated: 03 Jan 2025

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Abstract

A novel application of mesenchymal stem cell-derived microvesicles (MSC-derived MVs) with arthrodesis in dogs is described, and radiographic osseous union, lameness score, histological findings, and complications following surgery are assessed. This study compared the procedure type in 20 cases of pan carpal arthrodesis in dogs treated with (MSCs derived MVs) and cancellous bone autografts (mixed group) and cancellous bone autografts alone (BG group). Radiographs were compared at 4, 8 and 12 weeks after surgery to find that the (MSCs derived MVs) group had greater scores than others in terms of radiographic osseous union and histopathological evidence of bone formation. When compared to the (MSCs derived MVs) group, the BG group had considerably more serious problems that necessitated re-operation for implant removal or treatment of a deep infection. Overall, MSC-derived microvesicles (MSC-derived MVs) can be used to complement arthrodesis in dogs without causing considerable morbidity

DOI

10.21608/vmjg.2021.212221

Keywords

arthrodesis, pan carpal, micro vesicle, stem cells

Authors

First Name

Amr

Last Name

Abdallah

MiddleName

H

Affiliation

Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

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Orcid

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First Name

Ahmed

Last Name

Abdelgalil

MiddleName

I

Affiliation

Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

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City

-

Orcid

-

First Name

Ashraf

Last Name

Shamaa

MiddleName

-

Affiliation

Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

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-

City

-

Orcid

-

First Name

Faisal

Last Name

Torad

MiddleName

A

Affiliation

Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

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Orcid

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Volume

67

Article Issue

1

Related Issue

23241

Issue Date

2021-12-01

Receive Date

2021-12-23

Publish Date

2021-12-01

Page Start

192

Page End

201

Print ISSN

1110-1423

Online ISSN

2537-1045

Link

https://vmjg.journals.ekb.eg/article_212221.html

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https://vmjg.journals.ekb.eg/service?article_code=212221

Order

17

Type

Original Article

Type Code

544

Publication Type

Journal

Publication Title

Veterinary Medical Journal (Giza)

Publication Link

https://vmjg.journals.ekb.eg/

MainTitle

Augmentation of Carpal Arthrodesis Using Mesenchymal Stem Cells Derived Microvesicles and Cancellous Bone Graft in Dogs

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Article

Created At

22 Jan 2023