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157542

Canine Adult-Onset Hypothyroidism: Prevalence, Clinical and Laboratory Findings with Special Reference to Therapeutic Approach

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Last updated: 03 Jan 2025

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Abstract

Hypothyroidism is one of the most common endocrinopathies in dogs, it is defined as a decrease in production of thyroid hormones. Hypothyroidism results in vague clinical of signs but metabolic and dermatological signs are the most reported manifestations. This investigation aimed to study canine hypothyroidism in terms of clinical, haemato- biochemical, and thyroid panel alterations and evaluate response to treatment in adult onset hypothyroidism in dogs' cosmopolitan in Cairo and Giza governorates. To crude determination of disease in dog cosmopolitan in Cairo and Giza governorates, multicenter study was conducted. In the period from December-2019 to May-2020, 220 dogs with various dermatologic signs represented to different clinics, after ruling out other causes, 40 with signs consistent with hypothyroidism were subjected to initial screening for hypothyroidism using TT4. Only 15 dogs showed decrease in TT4 and these dogs were further investigated, additional 8 clinically healthy dogs enrolled as control group. Blood sample was taken from both hypothyroid dogs [N=15] and control dogs [N=8] for hematology analysis, TT4, fT4, TSH. Cholesterol, ALT and ALP. Diseased group [15 dogs] were treated with levothyroxine and re-evaluated after 1-month period. Overall prevalence of hypothyroidism in this investigation was 7.5 percent. Significant decrease in RBCs, PCV, TT4 and fT4 along with non-significant increase in TSH and cholesterol were recorded in hypothyroid patients compared to control group. Treatment with levothyroxine caused thyroid hormones to be within normal reference range. The Prevalence of hypothyroidism in studied cases in this investigation was 7.5 % and is similar to the reported prevalence; diagnosis of hypothyroidism should be relying on combination of clinical and laboratory data. Usage of human levothyroxine can successfully manage caninehypothyroidism.

DOI

10.21608/vmjg.2020.157542

Keywords

hypothyroidism, dogs, Levothyroxine, Thyroid panel

Authors

First Name

Noha

Last Name

Ryad

MiddleName

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Affiliation

Department of Internal Medicine and Infectious diseases, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

Email

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City

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Orcid

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First Name

Eman

Last Name

Ramadan

MiddleName

-

Affiliation

Department of Internal Medicine and Infectious diseases, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

Email

-

City

-

Orcid

-

First Name

Noha

Last Name

Salem

MiddleName

-

Affiliation

Department of Internal Medicine and Infectious diseases, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

Email

-

City

-

Orcid

-

First Name

I

Last Name

Saleh

MiddleName

-

Affiliation

Department of Internal Medicine and Infectious diseases, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

Email

-

City

-

Orcid

-

Volume

66

Article Issue

1

Related Issue

23198

Issue Date

2020-12-01

Receive Date

2020-01-17

Publish Date

2020-12-01

Page Start

10

Page End

18

Print ISSN

1110-1423

Online ISSN

2537-1045

Link

https://vmjg.journals.ekb.eg/article_157542.html

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https://vmjg.journals.ekb.eg/service?article_code=157542

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2

Type

Original Article

Type Code

544

Publication Type

Journal

Publication Title

Veterinary Medical Journal (Giza)

Publication Link

https://vmjg.journals.ekb.eg/

MainTitle

Canine Adult-Onset Hypothyroidism: Prevalence, Clinical and Laboratory Findings with Special Reference to Therapeutic Approach

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Article

Created At

22 Jan 2023