The aim of the present study was to investigate the antioxidant and hepatoprotective effects of ginger and fish oil against oxidative stress induced by atherosclerotic diet that enhanced hepatic changes in rats. The animals were divided into four groups of twelve rats each. Group I served as the control. Rats in groups II, III and IV were fed with an atherogenic diet for 8 weeks, group III received atherogenic diet supplemented with 5% ginger, and group IV received atherogenic diet supplemented with 10 % fish oil. Hypercholesterolemia was confirmed by significant elevation of total cholesterol. The protective role of those treatments was confirmed by the significant reduction in the elevated liver enzymes (AST, ALT and ALP levels) and increase in total antioxidant capacity (TAC), catalase (CAT) activity and glutathione reduced (GSH) levels , while malondialdehyde (MDA) levels was significantly reduced when compared with hypercholesterolemic group. We concluded that ginger and fish oil have modulatory effects on antioxidant status and liver functions in hypercholesterolemic male rats.