Canine Gastrointestinal Disorders is fairly common encounter in canine practice. Nevertheless, investigations of new underline causes options have been limited. This study carried out for assessing the role of histamine, as a player canine gastrointestinal disorders and adverse food reaction. This is a, controlled Study over a period of 25 months, designed for evaluation the role of histamine in canine gastrointestinal disorders, 16 adult dogs suffering from canine gastrointestinal disorders inclusion criteria were diarrhea, and vomiting which had been present for at least one day. Animals showed good responses to intramuscular injection of H1R antagonist; pheniramine maleate and consequently the gastrointestinal disorders diminished, dogs were tolerated the treatment, and there were no adverse effects. Therefore, H1R antagonist may be an alternative treatment option for patients with canine gastrointestinal disorders.
The success rate seems to be a promising option for the future treatment of canine gastrointestinal disorders in dogs. The use of H1R antagonists will provide an additional choice beside H2R blockers for the therapeutic options to treat GIT disorders in dogs. Results obtained in the present study showed that serum histamine level as well as symptoms had been decreased significantly after treatment