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156217

The use of ultasonication for preparation of nano-adjuvant rabies inactivated vaccine

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Last updated: 03 Jan 2025

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Abstract

The use of engineered nanomaterials (ENMs) that possess unique physicochemical properties in adjuvants enable researchers to achieve improved protection against infectious diseases. Recently, several studies were conducted on the use of nanoparticles as adjuvant to enhance the   immunogenicity of antigen and decrease the dose of immunologic adjuvants. In this work, we synthesized aluminum hydroxide nanoparticles using sonochemical technique nanoparticles, were characterized using X-ray diffraction, high resolution transmission electron microscope and zeta size potential. The result demonstrated that the size of aluminum hydroxide nanoparticles was 51 nm in diameter  that exhibited more potent antigen-specific antibody response than that of the micro-sized aluminum hydroxide gel particles (9 mm), so the prepared nano aluminum hydroxide was used as adjuvant for the inactivated rabies vaccine comparing with the traditional aluminum hydroxide gel and  the dose of  the prepared inactivated nana rabies vaccine was reduced, inducing high prolonged potent immune response in vaccinated dog.

DOI

10.21608/vmjg.2018.156217

Authors

First Name

Amany

Last Name

El-zieny

MiddleName

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Affiliation

Department of Rabies , Veterinary Serum and Vaccine Research Institute, Abbassia, Cairo, Egypt

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First Name

A

Last Name

Soliman

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Affiliation

Department of Rabies , Veterinary Serum and Vaccine Research Institute, Abbassia, Cairo, Egypt

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Orcid

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First Name

S

Last Name

ElDek

MiddleName

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Affiliation

Materials Science and Nanotechnology Department, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Beni-Suef, Egypt

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Orcid

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First Name

A

Last Name

Farghali

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-

Affiliation

Materials Science and Nanotechnology Department, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Beni-Suef, Egypt

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Volume

64

Article Issue

1

Related Issue

22953

Issue Date

2018-12-01

Receive Date

2018-01-01

Publish Date

2018-12-01

Page Start

51

Page End

63

Print ISSN

1110-1423

Online ISSN

2537-1045

Link

https://vmjg.journals.ekb.eg/article_156217.html

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https://vmjg.journals.ekb.eg/service?article_code=156217

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5

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Original Article

Type Code

544

Publication Type

Journal

Publication Title

Veterinary Medical Journal (Giza)

Publication Link

https://vmjg.journals.ekb.eg/

MainTitle

The use of ultasonication for preparation of nano-adjuvant rabies inactivated vaccine

Details

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Article

Created At

22 Jan 2023