Beta
ManageSearchChatDiscover
155935

Studies on the using of 2-Phenoxyethanol as an alternative to Thiomersal as a preservative in Foot-and-Mouth Disease vaccine

Article

Last updated: 03 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

The control of foot-and-mouth disease (FMD) in animals was considered to be important to effectively contain the disease in endemic areas, so that vaccination of animals is effective in limiting the spread of the disease. The progress in FMD vaccine production directed primarily towards the safety of the vaccine, purity of the antigen and selection of proper additives as adjuvants and preservatives.Thimerosal (Merthiolate) has been used as a preservative since 1930. Nevertheless, Thiomersal itself proved to be very toxic because it containsmercury. Hence, the current article discussed the cause and the prevention measures of the pyrogen-free colored sediment that might appear in the vaccine formula. Where the etiology might appear in the biological product was approached and solved. Besides, 2-phenoxyethanol was examined as an alternative preservative in FMD vaccine. The results of the examined samples (virus, vaccine, and milk), using the later preservative, showed no formation of sediment and no changes in colors. In addition, 2-phenoxyethanol had no cytotoxic effect on BHK. It showed safety and efficacy as substitution preservative.

DOI

10.21608/vmjg.2018.155935

Keywords

Foot-and-Mouth disease virus, thiomersal, 2-phenoxyethanol

Authors

First Name

Hany

Last Name

Abu-Elnaga

MiddleName

-

Affiliation

Department of Foot and Mouth Disease, Veterinary Serum and Vaccine Research Institute, Abbassia, Cairo, Egyp PO Box 131. Postal No.11381.

Email

h.abu-elnaga@hotmail.com

City

-

Orcid

-

First Name

Sonia

Last Name

Rizk

MiddleName

-

Affiliation

Department of Foot and Mouth Disease, Veterinary Serum and Vaccine Research Institute, Abbassia, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

Hind

Last Name

Dauod

MiddleName

-

Affiliation

Department of Foot and Mouth Disease, Veterinary Serum and Vaccine Research Institute, Abbassia, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

Akram

Last Name

Hegazy

MiddleName

-

Affiliation

Department of Foot and Mouth Disease, Veterinary Serum and Vaccine Research Institute, Abbassia, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

Walaa

Last Name

Shabana

MiddleName

-

Affiliation

Department of Foot and Mouth Disease, Veterinary Serum and Vaccine Research Institute, Abbassia, Cairo, Egypt.

Email

-

City

-

Orcid

-

Volume

64

Article Issue

1

Related Issue

22953

Issue Date

2018-12-01

Receive Date

2018-01-01

Publish Date

2018-12-01

Page Start

14

Page End

22

Print ISSN

1110-1423

Online ISSN

2537-1045

Link

https://vmjg.journals.ekb.eg/article_155935.html

Detail API

https://vmjg.journals.ekb.eg/service?article_code=155935

Order

2

Type

Original Article

Type Code

544

Publication Type

Journal

Publication Title

Veterinary Medical Journal (Giza)

Publication Link

https://vmjg.journals.ekb.eg/

MainTitle

Studies on the using of 2-Phenoxyethanol as an alternative to Thiomersal as a preservative in Foot-and-Mouth Disease vaccine

Details

Type

Article

Created At

22 Jan 2023