Pica is a fairly common condition in small ruminants. This study aimed to investigate changes occur in hematology, serum biochemical, mineral, MDA and thyroid hormones in pica affected sheep. The present study was conducted on 7 native breed sheep aged "1year-2.5years", of both sexes (5 females and 2 males) and five apparently healthy sheep from same locality were used as control. Clinical, physical, skin scraping and fecal samples were examined. Blood samples were withdrawn for hematologic investigation; TP, albumin, BUN, creatinine, cholesterol, and triglyceride, Zn, Cu, Ca, Ph, Mg, Malondialdehyde (MDA), T3 and T4 were estimated in serum and heparinized plasma. Significant reduction in RBCs, Hb, PCV, TP, and albumin, Zn, Cu, Ph and Fe along with non-significant increase in BUN, Cholesterol and MDA were recorded. Non-significant reduction in thyroid hormones observed. In conclusion, Allotrophagia appeared to be strongly correlated with mineral status in animal and have an impact on oxidative stress marker (MDA) and hemato-biochemical constituents with minimal effect on thyroid hormones.