Diabetic peripheral neuropathy (DPN) can injure the hand median nerve and cause extensive nerve damage. Neurodegenerative diseases (NDs) represent a large group of neurological disorders with heterogeneous clinical and pathological expressions affecting specific subsets of neurons in specific functional anatomic systems. An early diagnosis for these diseases strongly improves the effectiveness of the available treatments, but it is still a challenging task. Handwriting analysis is a method of predicting the writer's personality and gaining deeper insight into the author. It is a technical method for defining and evaluating author behaviors from handwriting based on line analysis. Handwriting results from a complex network made up of cognitive, kinesthetic, and perceptual-motor abilities . Standard handwriting tests used to support disorder diagnoses is the DPN. It inspects such handwriting characteristics as: legibility, handwriting speed, form, alignment, size and spacing . DPN handwritings showed high speed with an imbalance in the writing pressure; changed acceleration; inside and on strokes edges; air strokes; natural tremors. These should be regraded as handwriting features of DPN and are not regular written defects, especially if they are present in the same positions with comparative signatures .