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257564

Multi-omics analysis of human gut microbiota in colorectal cancer patients

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Microbiology and biotechnology

Abstract

Colorectal cancer (CRC) is a critical health problem. It is the second cause of death globally and the third world's most frequently diagnosed. Multiple evidences and suggestion imply the relationship of gut microbiota and colorectal cancer carcinogenesis. The different omics techniques like, metagenomic, metaproteomic and metabolomic approaches have led to important advances in the study of the intestinal microbiome, the host as well as the intestinal environment. Different bacterial species, proteins and metabolites have a crucial role in colorectal cancer screening, detection and recurrence. Integration of these three omics analysis in drawing attention to reveal taxonomic and functional structure of human gut microbiota in addition several protein and metabolites detection had helped in construction of microbial communities and their diversity in colorectal cancer patients and healthy controls besides that these bacterial species, metabolites and proteins could be used as a critical biomarkers candidate in colorectal cancer detection, prognosis and recurrence.

DOI

10.21608/rpbs.2022.154796.1161

Keywords

colorectal cancer, Metagenomic, Metaproteomic, Metabolomic, gut microbiota

Authors

First Name

Rana

Last Name

Abo-Hammam

MiddleName

Hashem

Affiliation

Forensic toxicologist and narcotic expert, Forensic medicine authority, Ministry of Justice, Egypt

Email

ranahashem111@hotmail.com

City

Tanta

Orcid

-

First Name

Randa

Last Name

Khattab

MiddleName

Hesham

Affiliation

Assisstant lecturer, Microbiology& Immunology department, AlSalam University, Egypt

Email

dr.randaheshamkh@hotmail.com

City

Tanta

Orcid

-

First Name

Mohammed

Last Name

Salah

MiddleName

-

Affiliation

Department of Microbiology and Immunology, Faculty of Pharmacy, Port said University, Egypt

Email

mohammedsalahatab@yahoo.com

City

-

Orcid

-

First Name

Samira

Last Name

Hamad

MiddleName

-

Affiliation

Department of Microbiology and Immunology, Faculty of Pharmacy, Suez canal University, Ismailia, Egypt

Email

samirazakeer2007@hotmail.com

City

Ismailia

Orcid

0000-0002-6764-5503

First Name

Sarah

Last Name

Shabayek

MiddleName

-

Affiliation

Department of Microbiology and Immunology, Faculty of Pharmacy, Suez canal University, Ismailia, Egypt

Email

sarahshabayek@yahoo.com

City

Ismailia

Orcid

-

First Name

Amro

Last Name

Hanora

MiddleName

-

Affiliation

Department of Microbiology and Immunology, Faculty of Pharmacy, Suez canal University, Ismailia, Egypt

Email

a.hanora@pharm.suez.edu.eg

City

Ismailia

Orcid

-

Volume

6

Article Issue

2

Related Issue

33245

Issue Date

2022-04-01

Receive Date

2022-08-07

Publish Date

2022-04-01

Page Start

141

Page End

146

Print ISSN

2536-9857

Online ISSN

2535-2091

Article File

RPBS_Volume 6_Issue 2_Pages 141-146.pdf

PDF . 490.2kB

Link

https://rpbs.journals.ekb.eg/article_257564.html

Detail API

https://rpbs.journals.ekb.eg/service?article_code=257564

Order

11

Type

Mini-reviews

Type Code

534

Publication Type

Journal

Publication Title

Records of Pharmaceutical and Biomedical Sciences

Publication Link

https://rpbs.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023