Artemisia judaica L. is widely spread in the desert and coast of the Mediterranean region. Traditionally, it had been used as a vermifuge, stomachic, sedative, antispasmodic, diabetes, fungal infections and arthritis. It is strongly aromatic, with bushy herbs, woody bases and sturdy spreading branches, covered by woolly hairs, crowded and short leaves, heads are made of tubular florets. Recently, A. judaica gained attention around the world because of its therapeutic and biological activities such as anti-inflammatory, analgesic, anti-oxidant activity andhigh potential antiangiogenic activity. In this review, we summarize the most important chemical constituents and biological activities A. judaica.