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231958

Prevalence of Scc-mecA, ermB, and fusidic acid-resistant genes in Staphylococcal species recovered from acne vulgaris in Eygpt

Article

Last updated: 22 Jan 2023

Subjects

-

Tags

Microbiology and biotechnology

Abstract

A multidrug-resistant Staphylococcal species including Staphylococcus aureus and Staphylococcus epidermidis that colonizing patients with acne Vulgaris were investigated for the presence of resistance determinants. Acne vulgaris patients are usually subjected to topical antibiotic treatment including erythromycin and fusidic acid as the first line of treatments, which have been associated with resistance development. In this study, we attempt to investigate the dissemination of resistance determinants exclusively related to fusidic acid antibiotics mainly the horizontally transmitted fusB and fusC genes using the polymerase chain reaction technique. Our results suggested amplified resistance to fusidic acid with a large abundance magnitude of fusC gene among methicillin-resistant Staphylococcus aureus isolates, while an increased abundance of fusB gene among Staphylococcus epidermidis isolates compared to other resistance determinants. Conclusion: patients with acne vulgaris who were subjected to previous fusidic acid treatments should consider treatment with alternative antibiotics other than fusidic acid to achieve maximum treatment benefits considering clindamycin and aminoglycoside.

DOI

10.21608/rpbs.2022.116697.1123

Keywords

Acne vulgaris, Fusidic acid, Staphyloccocus aureus, Staphyloccocus epidermidis

Authors

First Name

Noha

Last Name

Hashem

MiddleName

Mahmoud

Affiliation

pharmacy, ministry of Health, Egypt.

Email

noha.mahmoud_22@yahoo.com

City

cairo

Orcid

-

First Name

Alaa EL Din

Last Name

Hosny

MiddleName

Shawky

Affiliation

Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University

Email

dr.alaa@hotmail.com

City

cairo

Orcid

-

First Name

Ali

Last Name

Abdelrahman

MiddleName

Abdellah

Affiliation

Department of Microbiology and Immunology, Faculty of Pharmacy, , Suez Canal University, Ismailia, Egypt.

Email

dr_ali_abdellah@yahoo.com

City

Ismailia

Orcid

-

First Name

Samira

Last Name

Hamad

MiddleName

Zakeer

Affiliation

microbiology and immunology department, faculty of pharmacy, suez canal university, Ismailia, Egypt

Email

samirazakeer2007@hotmail.com

City

Ismailia

Orcid

0000-0002-6764-5503

Volume

6

Article Issue

2

Related Issue

33245

Issue Date

2022-04-01

Receive Date

2022-01-16

Publish Date

2022-04-01

Page Start

5

Page End

11

Print ISSN

2536-9857

Online ISSN

2535-2091

Link

https://rpbs.journals.ekb.eg/article_231958.html

Detail API

https://rpbs.journals.ekb.eg/service?article_code=231958

Order

2

Type

Original Article

Type Code

532

Publication Type

Journal

Publication Title

Records of Pharmaceutical and Biomedical Sciences

Publication Link

https://rpbs.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023