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231956

Mannose binding lectin defects and autoimmune diseases

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Microbiology and biotechnology

Abstract

Complement system has a very important role in our defense against different pathogens and harmful immune complexes. The lectin pathway of complement system is activated by mannose binding lectin leading to complement cascade ending with the removal of these invading pathogens and the injuring immune complexes. Defects in mannose binding lectin were found to be associated with MBL2 gene polymorphisms such as exon 1 polymorphisms and promotor region polymorphisms. These defects were linked to serious autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. The aim of our review is to provide an overview of mannose binding lectin role in complement system and to outline the information about mannose binding lectin defects with systemic lupus erythematosus and rheumatoid arthritis in addition to the possible related explanations. Mannose binding lectin variants were believed to have an association with these autoimmune disorders by many studies with the presence of conflicted studies as well.

DOI

10.21608/rpbs.2022.112972.1121

Keywords

complement, mannose binding lectin, Polymorphisms, Autoimmune

Authors

First Name

Mohammed

Last Name

Behairy

MiddleName

yehya

Affiliation

Department of Microbiology and Immunology, Faculty of pharmacy, University of Sadat City, Egypt

Email

mohamedyehya950@gmail.com

City

Ismailia

Orcid

-

First Name

Ali

Last Name

Abdelrahman

MiddleName

Abdellah

Affiliation

Department of Microbiology and Immunology, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt

Email

dr_ali_abdellah@yahoo.com

City

-

Orcid

-

First Name

Hoda

Last Name

Abdallah

MiddleName

-

Affiliation

Department of Histology and Cell Biology (Genetics Unit), Faculty of Medicine, Suez Canal University, 41522, Ismailia, Egypt; Center of Excellence in Molecular and Cellular Medicine, Faculty of Medicine, Suez Canal University, 41522, Ismailia, Egypt.

Email

hoda_ibrahim1@med.suez.edu.eg

City

-

Orcid

-

First Name

Emad Eldin

Last Name

Ibrahim

MiddleName

Ahmed

Affiliation

Department of Anesthesia and Intensive care, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Email

ee_ahmed@yahoo.com

City

-

Orcid

-

First Name

Hany

Last Name

Hashem

MiddleName

-

Affiliation

Department of Microbiology and Immunology, Faculty of Pharmacy, Fayoum University, Fayoum, Egypt

Email

hra11@fayoum.edu.eg

City

-

Orcid

-

First Name

Marwa

Last Name

Azab

MiddleName

-

Affiliation

Department of Microbiology and Immunology, Faculty of Pharmacy, Suez Canal university, Ismailia, 41522, Egypt;

Email

marwaazab2515@yahoo.com

City

ismailia

Orcid

0000-0001-6786-4493

Volume

6

Article Issue

2

Related Issue

33245

Issue Date

2022-04-01

Receive Date

2021-12-25

Publish Date

2022-04-01

Page Start

1

Page End

4

Print ISSN

2536-9857

Online ISSN

2535-2091

Article File

RPBS_Volume 6_Issue 2_Pages 1-4.pdf

PDF . 381.3kB

Link

https://rpbs.journals.ekb.eg/article_231956.html

Detail API

https://rpbs.journals.ekb.eg/service?article_code=231956

Order

1

Type

Mini-reviews

Type Code

534

Publication Type

Journal

Publication Title

Records of Pharmaceutical and Biomedical Sciences

Publication Link

https://rpbs.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023