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231970

A Comprehensive Overview of Lipid-Based Drug Delivery Approach

Article

Last updated: 03 Jan 2025

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Subjects

-

Tags

Industrial pharmacy

Abstract

The majority of the pharmaceutically active chemical moieties represent a challenge in their formulation. Most of these drugs have intricate bioavailability issues either related to their low solubility or permeability. Many problems may arise during formulations such as pH dependent ionization, poor drug solubility, limited absorption, unpredicted bioavailability, degradation, metabolism, and cellular efflux. Poor aqueous solubility is a determinate criterion, during formulation and Biopharmaceutical Classification System (BCS) categorization. Among the most important approaches to enhance solubility, the Lipid-Based Drug Delivery Systems (LBDDS). The strategies involving lipid incorporation was a revolutionary step and included: vesicular systems, lipid particulate systems and emulsions.

DOI

10.21608/rpbs.2022.231970

Keywords

BCS, LBDDS, vesicular systems, Lipid particulate, Emulsions

Authors

First Name

Noha

Last Name

Abourobe

MiddleName

M.

Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt

Email

otella.mostafa@gmail.com

City

-

Orcid

-

First Name

Tamer

Last Name

Hassan

MiddleName

H.

Affiliation

Pharmaceutics & Industrial Pharmacy Department, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt.

Email

tamer_hassan@pharm.suez.edu.eg

City

Ismailia

Orcid

0000-0002-9770-0382

First Name

shadeed

Last Name

Gad

MiddleName

-

Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt

Email

gads@tcd.ie

City

-

Orcid

-

First Name

Yasser

Last Name

Mostafa

MiddleName

Mohamed

Affiliation

Department of Pharmacology & Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt University, Ismailia 41522, Egypt, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Badr University, Badr City, Egypt.

Email

moustafayasser@yahoo.com

City

Ismailia

Orcid

-

Volume

6

Article Issue

3

Related Issue

33244

Issue Date

2022-04-01

Receive Date

2022-04-19

Publish Date

2022-04-01

Page Start

59

Page End

68

Print ISSN

2536-9857

Online ISSN

2535-2091

Article File

RPBS_Volume 6_Issue 3_Pages 59-68.pdf

PDF . 778.3kB

Link

https://rpbs.journals.ekb.eg/article_231970.html

Detail API

https://rpbs.journals.ekb.eg/service?article_code=231970

Order

5

Type

Mini-reviews

Type Code

534

Publication Type

Journal

Publication Title

Records of Pharmaceutical and Biomedical Sciences

Publication Link

https://rpbs.journals.ekb.eg/

MainTitle

A Comprehensive Overview of Lipid-Based Drug Delivery Approach

Details

Type

Article

Created At

22 Jan 2023