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186036

Anti-Diabetic Medications: A promising therapeutic approaches for the Management of NAFLD

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Pharmacology and toxicology

Abstract

Type 2 diabetes and Nonalcoholic fatty liver disease are two of the most common metabolic diseases in the world, with an increasing prevalence. Patients with T2DM have a two-fold increased risk of developing NAFLD, The evidence that certain antidiabetic drugs boost NAFLD/NASH in T2DM patients is growing. However, there are no specific pharmacologic treatments available. This review aims to outline the data supporting the effectiveness of anti-diabetic drugs in the treatment of NAFLD, besides providing an overview of novel anti-diabetic therapies that have been proposed to achieve this goal. Most of these anti-diabetic agents demonstrate short-term efficacy, but have shown little to no impact on hepatic histology. Only thiazolides and GLP-1 receptor agonists have shown considerable improvement in hepatic histology.

DOI

10.21608/rpbs.2021.79353.1103

Keywords

GLP-1, Steatohepatitis, diabetes, NAFLD

Authors

First Name

ahmed

Last Name

ibrahim

MiddleName

-

Affiliation

Department of Pharmacology & Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt

Email

ahmed.z.ibrahim@pharm.suez.edu.eg

City

ismailia

Orcid

-

First Name

Reem

Last Name

Hazem

MiddleName

mohamed

Affiliation

Department of Pharmacology &Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt.

Email

reem_ahmed@pharm.suez.edu.eg

City

Ismailia

Orcid

-

First Name

Dina

Last Name

Ali

MiddleName

Abdelkarim

Affiliation

Department of clinical Pharmacology, Faculty of Medicine, Suez Canal University, Ismailia 41522, Egypt

Email

dina_abdel-karim@med.suez.edu.eg

City

-

Orcid

-

First Name

Yasser

Last Name

Moustafa

MiddleName

mohamed

Affiliation

Pharmacology and Toxicology Department, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt.

Email

yasser_mostafa@pharm.suez.edu.eg

City

Ismailia

Orcid

-

Volume

5

Article Issue

Pharmacology-Pharmaceutics

Related Issue

20377

Issue Date

2021-01-01

Receive Date

2021-06-06

Publish Date

2021-01-01

Page Start

65

Page End

70

Print ISSN

2536-9857

Online ISSN

2535-2091

Article File

RPBS_Volume 5_Issue Pharmacology-Pharmaceutics_Pages 65-70.pdf

PDF . 585.8kB

Link

https://rpbs.journals.ekb.eg/article_186036.html

Detail API

https://rpbs.journals.ekb.eg/service?article_code=186036

Order

8

Type

Mini-reviews

Type Code

534

Publication Type

Journal

Publication Title

Records of Pharmaceutical and Biomedical Sciences

Publication Link

https://rpbs.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023