The skin is known to be the primary intact skin layer for the application of cosmetics and medicines. These nanocarriers, however, can enhance the distribution of molecules through hair follicles or impart a regulated pattern of release by making depots on the skin.. moreover, Many challenges may potentially face the topical delivery of medicaments through either the healthy or diseased skin. This is mainly owing to the strong protection offered by the barriers made of the skin. This paper displays the blocking nature of the skin, the difficult conditions of skin inflammatory diseases, options of effective treatment, and general categories of advanced topical drug delivery for better efficacy and safety. Solid lipid nanoparticles and other lipid-based nanocarriers are mentioned particularly with a further focus along with examples of opportunities for bioavailability enhancement of poorly absorbed active moieties and for more promising implementation in convenient and efficient topical remediation of skin inflammatory disorders.