In this article, we offer a summary of a broad variety of colloidal drug delivery systems with a special emphasis on vesicular used in testing or theoretically useful as carrier systems for medicines or active biomolecules or as cell carriers with therapeutic use. They provide several significant details of the currently developed drug delivery systems for academic or clinical applications. This series of systems are commonly used due to outstanding drug tracking, continuous and regulated release behavior, improved drug molecules clogging performance, avoidance of product hydrolysis or enzymatic degradation, and therapeutic efficacy improvements. Such characteristics aid in the discovery of suitable carrier structures for the transmission of medicines, cells, and genes in various fields. Colloidal drug delivery systems play a significant role in drug delivery. In my opinion, all colloidal carriers present notable characteristics after application. These vesicles can deliver an active compound through the biological membranes via absorption, fusion, and to raise the quantity of permeated drugs compared with conventional formulations.