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160651

Antibiotics profile and b-lactamases in Pseudomonas aeruginosa

Article

Last updated: 22 Jan 2023

Subjects

-

Tags

Microbiology and biotechnology

Abstract

Pseudomonas aeruginosa most strains are motile by means of a single polar flagellum. It usually lives in moist environments and uses a wide range of organic compounds for growth, this giving it an exceptional ability to penetrate plant and animal tissues. P.aeruginosa colonizes human body sites, mainly the moist areas, such as the ear, nasal mucosa and throat, as well as stools. It contains 163 known or predicted porin proteins based on its genome sequence, 64 are found as part of 3 families of porins, the OprD-specific porin family, the TonB-dependent gated porin family and the OprM efflux family. β-lactamases are normally located in the periplasm, but it has been detected during the antipseudomonal treatment in the sputum, these enzymes are highly released from high level producers in the lungs. MBL are characterized with zinc ion as a cofactor and with a separate heritage, the common feature of MBLs is the principal zinc binding Histidine-X‌histidine-XAspartic acid in the active site, which coordinates the arrangement of two H2O molecules that are important in the hydrolysis. The chelation of zinc by EDTA or mercaptopropionic acid, impairs β-lactam hydrolysis and restores susceptibility to Carbapenems. MBLs have a wide active site, which let all β-lactams to accomodate in there, except Aztreonam. β-lactamase inhibitors such as clavulanic acid, Tazobactam and Sulbactam are also hydrolised by MBLs. This review was done to figure out the antimicrobial profile and the different β-lactamases present in Pseudomonas aerugionosa

DOI

10.21608/rpbs.2021.66592.1095

Keywords

Pseudomonas aeruginosa, metalloβ-lactamases, carbapenems

Authors

First Name

Dalia

Last Name

Hamed

MiddleName

Mohsen

Affiliation

Department of Quality control, VACSERA, Giza, Egypt,

Email

daliamohsen80@gmail.com

City

Cairo

Orcid

-

Volume

5

Article Issue

Pharmacognosy-Microbiology

Related Issue

20371

Issue Date

2021-01-01

Receive Date

2021-03-07

Publish Date

2021-01-01

Page Start

74

Page End

79

Print ISSN

2536-9857

Online ISSN

2535-2091

Link

https://rpbs.journals.ekb.eg/article_160651.html

Detail API

https://rpbs.journals.ekb.eg/service?article_code=160651

Order

8

Type

Mini-reviews

Type Code

534

Publication Type

Journal

Publication Title

Records of Pharmaceutical and Biomedical Sciences

Publication Link

https://rpbs.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023