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144658

Anti-inflammatory Properties of the Crude Extract of Phyllostachys heterocycla in Two Different Models of Acute Inflammation in Experimental Rats

Article

Last updated: 22 Jan 2023

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Subjects

-

Tags

Chemistry of natural products

Abstract

The crude methanolic extract of Phyllostachys heterocycla was examined for the anti-inflammatory activity in rats using two different models of paw inflammation. Induction of edema was performed using 1% carrageenan in the first model and 2.5% formalin in the second model. The extract powder was dissolved in tween 80 and given orally for six consecutive days. Treatment with two doses (250 mg/kg and 500 mg/kg) of the extract of Phyllostachys heterocycla caused a dose-dependent reduction of paw thickness in both models. The anti-inflammatory effect of the crude extract of Phyllostachys heterocycla was also evaluated by determination of the serum levels of four inflammatory markers, where the serum levels of NF- κB, TNF-α, IL-1β and IL-6 were markedly increased in both models compared to the normal rats, with greater numbers recorded in the carrageenan-induced group. Treatment with both doses of the extract of Phyllostachys heterocycle led to a significant reeducation in all the detected markers in both the carrageenan and the formalin induced models, especially in case of the higher dose (500 mg/kg) that showed almost no significant different results compared to the normal group. In conclusion, the current preliminary study reports strong anti-inflammatory properties of Phyllostachys heterocycle extract.

DOI

10.21608/rpbs.2021.60202.1091

Keywords

Phyllostachys heterocycle, Rat paw edema, inflammatory markers, Anti-inflammatory

Authors

First Name

Ahmed

Last Name

Ibrahim

MiddleName

K.

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.

Email

ahmedkhider1993@gmail.com

City

Ismailia, Egypt

Orcid

0000-0002-1945-9327

First Name

Eman

Last Name

Mehanna

MiddleName

T.

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt

Email

eman.taha@pharm.suez.edu.eg

City

-

Orcid

0000-0003-2759-2889

First Name

Reda

Last Name

Abdelhameed

MiddleName

F.A.

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt

Email

omarreda_70@yahoo.com

City

ismaili

Orcid

-

First Name

Eman

Last Name

Habib

MiddleName

S.

Affiliation

pharmacognosy department,faculty of pharmacy,Suez canal university,Ismailia,Egypt.

Email

emansnd@yahoo.com

City

ismailia

Orcid

-

First Name

Koji

Last Name

Yamada

MiddleName

-

Affiliation

Garden for Medicinal Plants, Graduate School of Biomedical Sciences, Nagasaki University, Bunkyo-machi 1-14, Nagasaki 852-8521, Japan

Email

kyamada@nagasaki-u.ac.jp

City

Nagasaki, Japan

Orcid

-

First Name

Safwat

Last Name

Ahmed

MiddleName

A.

Affiliation

Faculty of Pharmacy - Suez Canal University

Email

safwat_ahmed@pharm.suez.edu.eg

City

Ismailia

Orcid

-

First Name

Amany

Last Name

Ibrahim

MiddleName

K.

Affiliation

Faculty of Pharmacy - Suez Canal University

Email

amany_mohamed@pharm.suez.edu.eg

City

Ismailia

Orcid

-

First Name

Jihan

Last Name

Badr

MiddleName

M.

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.

Email

jihanbadr2010@hotmail.com

City

Ismailia, Egypt

Orcid

-

Volume

5

Article Issue

Pharmacognosy-Microbiology

Related Issue

20371

Issue Date

2021-01-01

Receive Date

2021-01-27

Publish Date

2021-01-01

Page Start

53

Page End

59

Print ISSN

2536-9857

Online ISSN

2535-2091

Article File

RPBS_Volume 5_Issue Pharmacognosy-Microbiology_Pages 53-59.pdf

PDF . 743.3kB

Link

https://rpbs.journals.ekb.eg/article_144658.html

Detail API

https://rpbs.journals.ekb.eg/service?article_code=144658

Order

5

Type

Original Article

Type Code

532

Publication Type

Journal

Publication Title

Records of Pharmaceutical and Biomedical Sciences

Publication Link

https://rpbs.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023