Nature stands as an infinite resource for drug development, novel chemotypes and pharmacophores. Natural products have high structural diversity and unique pharmacological activities that can be used in treating various kinds of diseases. They have been the backbone for almost half of U.S. Food and Drug Administration (FDA) approved drugs .Medicinal plants have been utilized by humans for millennia as they serve as safe and effective therapeutic agents. Asteraceae is the largest family of plant kingdom with more than 25,000 species around the globe. Chiliadenus Cass., a small genus of ten species of the Inuleae-Inulineae of the daisy family (Asteraceae) consisting of ten species with allopatric distributions along the southern edge of the Mediterranean Sea. Phytochemical investigation of chiliadenus genus afforded the isolation of numerous natural compounds of several classes. The current review revealed that genus Chiliadenus is a precious source of monoterpenes, sesquiterpenes, diterpenes and methoxy flavonoids and it possesses several medicinal uses.