Nature has bestowed on people a very rich botanical wealth including a large number of naturally occurring plants in different parts of the world. Natural products from plant resources, including bio-molecules and secondary metabolites, usually exhibit some kind of biological activities in traditional and modern medicine. The Sinai peninsula is considered a repository of indigenous medicinal plants that have been used for hundreds of years for treatment of human ailments. Jasonia montana [Chiliadenus montanus] belongs to family Asteraceae, one of the largest families of flowering plants. It commonly grows in the Mediterranean region as well as the Sinai Peninsula, locally known as Haneida. The plant has a strong pleasant aromatic odor and is used in folk medicine for diarrhea, stomach-ache and chest diseases. Recent studies suggested that most of the reported biological activities of J. montana are due to its rich content of polyphenols, particularly flavonoids. This review highlights the phytochemical constituents of this important plant as well as its different reported biological activities.