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135144

The role of novel genes in rheumatoid arthritis pathogenesis

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Biochemistry and molecular biology

Abstract

Rheumatoid arthritis (RA) is a debilitating disease characterized by chronic symmetric polyarthritis involving peripheral small joints. Heterogeneity in RA pathophysiology extends to a molecular level. Understanding the complicated interaction between genetics, environment, and autoimmunity, and their function in pathogenesis, is necessary for getting further insight into the mechanisms and outcomes that manage disease development and progression. Pharmacogenomics emphasizes the relations of numerous genetic signatures with responses to traditional disease-modifying drugs and biologics. More than 100 genetic susceptibility loci have been recognized for RA through studies directed on patients with longstanding RA compared with healthy controls. So the interaction between genes and the environment may determine who is more susceptible to develop RA. This review pays attention to some recently discovered genetic risk loci in RA; ZNF804a, CDK1, YWHAH 14-3-3 η, and IL-17A. Also, their involvement in the etiology, pathogenesis, and outcome of the disease is explained, aiming to provide new insights into the pathogenesis of RA and the possibility to develop novel therapeutic approaches through targeting these genes.

DOI

10.21608/rpbs.2020.35330.1071

Keywords

ZNF804a, CDK1, 14-3-3 η, YWHAH, IL-17A

Authors

First Name

Shaimaa

Last Name

Fattah

MiddleName

-

Affiliation

Department of biochemistry, faculty of pharmacy, Suez Canal university, Ismailia, 41522, Egypt

Email

shimaa_abdaziz@pharm.suez.edu.eg

City

-

Orcid

0000-0001-7054-583X

First Name

Maha

Last Name

Abdel Fattah

MiddleName

-

Affiliation

Department of Physical Medicine, Rheumatology and Rehabilitation, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Email

dr.mahaabdelfattah86@gmail.com

City

-

Orcid

-

First Name

Eman

Last Name

Mehanna

MiddleName

T.

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt

Email

eman.taha@pharm.suez.edu.eg

City

-

Orcid

0000-0003-2759-2889

First Name

Noha

Last Name

Mesbah

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, 41522 Ismailia, Egypt

Email

noha_mesbah@pharm.suez.edu.eg

City

-

Orcid

0000-0002-8863-968X

First Name

Samy

Last Name

Saleh

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, 41522 Ismailia, Egypt

Email

samy_saleh2001@yahoo.com

City

-

Orcid

-

First Name

Dina

Last Name

Abo-El-Matty

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, 41522 Ismailia, Egypt

Email

dinawahadan@yahoo.com

City

Ismailia

Orcid

0000-0002-6074-2714

Volume

5

Article Issue

Chemistry

Related Issue

16063

Issue Date

2021-01-01

Receive Date

2020-08-27

Publish Date

2021-01-01

Page Start

18

Page End

27

Print ISSN

2536-9857

Online ISSN

2535-2091

Article File

RPBS_Volume 5_Issue Chemistry_Pages 18-27.pdf

PDF . 793.2kB

Link

https://rpbs.journals.ekb.eg/article_135144.html

Detail API

https://rpbs.journals.ekb.eg/service?article_code=135144

Order

6

Type

Mini-reviews

Type Code

534

Publication Type

Journal

Publication Title

Records of Pharmaceutical and Biomedical Sciences

Publication Link

https://rpbs.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023