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98582

A:The potential antioxidant and anti-inflammatory effects of catechins polyphenolic compounds in tea and cocoa extracts on STZ diabetic rats

Article

Last updated: 22 Jan 2023

Subjects

-

Tags

Biochemistry and molecular biology

Abstract

The aim of this study is to investigate the effect of some phenolic compounds such as catechines that heavily present in tea and cocoa extracts against diabetic induction using streptozotocin (STZ) treated rats. Eighty male albino rats were divided into eight groups of ten rats each as follows; normal,  black tea, green tea, cocoa , STZ- diabetic, STZ- diabetic + black tea,  STZ- diabetic + green tea, STZ- diabetic + cocoa. Blood glucose, glycosylated hemoglobin, serum insulin and lipid profile were assessed in all groups. In addition, HOMA-IR and atherogenic index were calculated. Further, inflammatory markers and other metabolic parameters such as endothelial dysfunction and oxidative stress markers were estimated. The data showed that all the used extracts had antioxidant and anti-inflammatory effect against STZ induced diabetes. Although, green tea extract showed the maximum improvement in antioxidants levels and cocoa extract showed the maximum improvement in inflammatory markers. We concluded that tea and cocoa extracts had a protective effect against STZ induced diabetes which attributed to their free radical scavenging antioxidants that reduced both the production and release of inflammatory markers.

DOI

10.21608/rpbs.2020.32285.1066

Keywords

diabetes, streptozotocin, Catechins

Authors

First Name

Asmaa

Last Name

Ramadan

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.

Email

asmaa.ramdan@pharm.suez.edu.eg

City

-

Orcid

-

First Name

Dina

Last Name

Abo-El-Matty

MiddleName

-

Affiliation

Faculty of Pharmacy - Suez Canal University

Email

dinawahadan@yahoo.com

City

Ismailia

Orcid

0000-0002-6074-2714

First Name

Omayma

Last Name

El-Darder

MiddleName

M

Affiliation

Department of Home Economics, Faculty of Education, Suez Canal University, Ismailia, Egypt

Email

omima_mohamed@edu.suez.edu.eg

City

-

Orcid

-

Volume

4

Article Issue

2

Related Issue

14947

Issue Date

2020-07-01

Receive Date

2020-06-11

Publish Date

2020-07-01

Page Start

39

Page End

49

Print ISSN

2536-9857

Online ISSN

2535-2091

Link

https://rpbs.journals.ekb.eg/article_98582.html

Detail API

https://rpbs.journals.ekb.eg/service?article_code=98582

Order

5

Type

Original Article

Type Code

532

Publication Type

Journal

Publication Title

Records of Pharmaceutical and Biomedical Sciences

Publication Link

https://rpbs.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023