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23373

Synthesis and Antimicrobial Evaluation of Novel Hydrazones and 1,3,4-Oxadiazoles Incorporating Bumetanide Derivatives

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Microbiology and biotechnology
Pharmaceutical chemistry.

Abstract

The aim of this study is to synthesize new benzenesulfonamide derivatives that possess antibacterial activity using Bumetanide as a precursor of benzenesulfonamide. A novel series of hydrazones containing benzenesulfonamides (4a-i) and 1,3,4 oxadiazole containing benzenesulfonamides (5a-e) were prepared and their antibacterial and antifungal activities were measured using microplate broth assay against Gram-positive: Staphylococcus aureus, Gram-negative: Escherichia coli and Pseudomonas aeruginosa and Fungi: Aspergillus fumigates and Candida albicans. The results showed that some of the prepared compounds exhibit a good to excellent activity against the mentioned bacteria, however all the series showed no activity against fungi. Among the series, Compound (4i) demoed an excellent antibacterial activity better than that of the standard reference (Sulfamethoxazole) against Escherichia coli, while compounds (4c, 4e, 4g) showed good activity against all tested bacterial strains equals to Sulfamethoxazole activity. Moreover, compounds (4g, 5d) exert an antimicrobial activity equals to that of Sulfamethoxazole against Pseudomonas aeruginosa, while compounds (4a, 4b, 4c, 4f, 4g, 4h) exhibit similar activity to Sulfamethoxazole against Escherichia coli.

DOI

10.21608/rpbs.2018.23373

Keywords

Bumetanide, Hydrazones, 1,3,4-oxadiazole, antimicrobial activity, benzenesulfonamide

Authors

First Name

Ibrahim

Last Name

Salem

MiddleName

Mostafa

Affiliation

Pharmaceutical Chemistry Departement, Faculty of Pharmacy, Suez Canal University

Email

dr_ibrahim_m@yahoo.com

City

Zagazig

Orcid

-

First Name

Samia

Last Name

Mostafa

MiddleName

M.

Affiliation

Pharmaceutical Chemistry Department, Suez Canal University, Faculty of Pharmacy, Ismailia, Egypt

Email

-

City

-

Orcid

-

First Name

Osama

Last Name

El-Sabbag

MiddleName

I.

Affiliation

Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt. , Pharmaceutical Chemistry Department, Faculty of Pharmacy, Taif University, Taif, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Tarek

Last Name

Ibrahim

MiddleName

S.

Affiliation

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt. , Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.

Email

tarekeldeeb1976@yahoo.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Abdulrahmanf

MiddleName

-

Affiliation

Department of Pharmaceutical chemistry, Faculty of Pharmacy, Port Said University, Port Said, Egypt

Email

-

City

-

Orcid

-

First Name

Mahmoud

Last Name

Bendary

MiddleName

M.

Affiliation

Department of Microbiology and Immunology, Faculty of Pharmacy, Port Said University, Port Said, Egypt

Email

mahmoud_m_bendary@yahoo.com

City

-

Orcid

-

Volume

2

Article Issue

2

Related Issue

4365

Issue Date

2018-09-01

Receive Date

2018-09-09

Publish Date

2018-09-01

Page Start

52

Page End

66

Print ISSN

2536-9857

Online ISSN

2535-2091

Article File

RPBS_Volume 2_Issue 2_Pages 52-66.pdf

PDF . 587.6kB

Link

https://rpbs.journals.ekb.eg/article_23373.html

Detail API

https://rpbs.journals.ekb.eg/service?article_code=23373

Order

6

Type

Original Article

Type Code

532

Publication Type

Journal

Publication Title

Records of Pharmaceutical and Biomedical Sciences

Publication Link

https://rpbs.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023