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5927

Development and evaluation of a floating in situ gelling liquid formulation of a locally acting H2-antagonist

Article

Last updated: 03 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Drug design and formulation

Abstract

In the present study, floating in situ gelling liquid formulation for controlled delivery of ranitidine was formulated using gellan gum (gelling polymer), calcium carbonate (gas-forming agent) and ranitidine. Gellan gum floating in situ gelling systems were prepared by dissolving varying concentrations of gellan gum in deionized water containing sodium citrate and calcium chloride, to which varying concentrations of drug and calcium carbonate were added and dissolved by continuous stirring. Prepared formulations were evaluated for viscosity, gelation behavior, floating properties (floating lag time and floating duration time), drug content and in-vitro drug release. Formulation variables such as concentration of gellan gum, calcium carbonate and drug signifcantly affected the formulation viscosity, floating behavior and in-vitro drug release. Analysis of the release kinetic data showed that the drug release from in situ gel followed a diffusion control mechanism.

DOI

10.21608/rpbs.2017.5927

Keywords

floating systems, In situ gelling, Controlled delivery, Gellan gum, Ranitidine

Authors

First Name

Hamdy

Last Name

Dawaba

MiddleName

M.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11651, Egypt

Email

hamdydawabah@azhar.edu.eg

City

-

Orcid

-

First Name

Aya

Last Name

Dawaba

MiddleName

M.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo 11651, Egypt

Email

-

City

-

Orcid

-

Volume

1

Article Issue

2

Related Issue

1064

Issue Date

2017-09-01

Receive Date

2018-04-07

Publish Date

2017-09-01

Page Start

36

Page End

44

Print ISSN

2536-9857

Online ISSN

2535-2091

Article File

RPBS_Volume 1_Issue 2_Pages 36-44.pdf

PDF . 759.5kB

Link

https://rpbs.journals.ekb.eg/article_5927.html

Detail API

https://rpbs.journals.ekb.eg/service?article_code=5927

Order

6

Type

Original Article

Type Code

532

Publication Type

Journal

Publication Title

Records of Pharmaceutical and Biomedical Sciences

Publication Link

https://rpbs.journals.ekb.eg/

MainTitle

Development and evaluation of a floating in situ gelling liquid formulation of a locally acting H2-antagonist

Details

Type

Article

Created At

22 Jan 2023