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5926

Investigation of the gastroprotective activity of some drugs in indomethacin-induced gastric lesion in rats

Article

Last updated: 03 Jan 2025

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Subjects

-

Tags

Pharmacology and toxicology

Abstract

Long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) increases the risk of severe gastric events. To minimize these risks, patients often require concomitant acid-suppressive therapy. This study was conducted to investigate the putative gastroprotective effect of sildenafl, verapamil and propranolol and possible mechanisms
underlying the effect of these drugs in experimentally-induced gastric lesions in rats. Rats were assigned to vehicle (saline), control (indomethacin, 30-mg/kg, p.o.), sildenafl (10-mg/kg, p.o.), verapamil (10 mg/kg, p.o.), propranolol (10 mg/kg, p.o.) and ranitidine (50-mg/kg, p.o); the drugs were administered 30-minute prior to indomethacin. After
4-hours, all rats were sacrifced, and stomach of each rat examined for gastric lesions either for biochemical or histopathological analysis. Indomethacin induced marked ulcerative lesions in form of strikes in the gastric mucosa. Furthermore, pre-treatment with sildenafl, verapamil, and propranolol signifcantly reduced gastric acid secretion,
ulcer scores, and lipid peroxides. Moreover, they markedly protect the stomach against indomethacin effect. The results confrm that each drug has a gastroprotective effect but with different mechanisms in prevention.

DOI

10.21608/rpbs.2017.5926

Keywords

Gastric ulcer, NSAIDs, Sildenafl, Verapamil, Propranolol

Authors

First Name

Dina

Last Name

Khodeer

MiddleName

M.

Affiliation

Department of Pharmacology & Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt

Email

hams_dina@yahoo.com

City

-

Orcid

-

First Name

Sawsan

Last Name

Zaitone

MiddleName

A.

Affiliation

Department of Pharmacology & Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia, Egyp

Email

-

City

-

Orcid

-

First Name

Elsayed

Last Name

Elawady

MiddleName

E.

Affiliation

Department of Pharmacology & Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt

Email

-

City

-

Orcid

-

First Name

Yasser

Last Name

Mostafa

MiddleName

M.

Affiliation

Department of Pharmacology & Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt

Email

-

City

-

Orcid

-

Volume

1

Article Issue

2

Related Issue

1064

Issue Date

2017-09-01

Receive Date

2017-04-13

Publish Date

2017-09-01

Page Start

25

Page End

35

Print ISSN

2536-9857

Online ISSN

2535-2091

Article File

RPBS_Volume 1_Issue 2_Pages 25-35.pdf

PDF . 1.0MB

Link

https://rpbs.journals.ekb.eg/article_5926.html

Detail API

https://rpbs.journals.ekb.eg/service?article_code=5926

Order

5

Type

Original Article

Type Code

532

Publication Type

Journal

Publication Title

Records of Pharmaceutical and Biomedical Sciences

Publication Link

https://rpbs.journals.ekb.eg/

MainTitle

Investigation of the gastroprotective activity of some drugs in indomethacin-induced gastric lesion in rats

Details

Type

Article

Created At

22 Jan 2023