Beta
ManageSearchChatDiscover
5924

Investigation of In-Vitro Cytotoxic and Potential Anticancer Activities of Flavonoidal Aglycones from Egyptian Propolis

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Chemistry of natural products

Abstract

The in-vitro anticancer activity of Egyptian propolis ethanol extract as well as two isolated flavonoidal aglycones, tectochrysin and quercetin-3,3'-di-O-methylether,was assayed using neutral red uptake method on human breast cancer (MCF-7) and colorectal adenocarcinoma (Caco-2) cell lines, in addition to their in-vitro cytotoxic effect to normal human peripheral blood mononuclear cells (PBMCs). Egyptian propolis ethanol extract and quercetin-3,3'-di-O-methylether showed both high activity and selectivity towards the two tested cell lines suggesting them as effective, safe and selective anticancer candidates against both breast and colorectal cancer.

DOI

10.21608/rpbs.2018.5924

Keywords

Propolis, Flavonoidal aglycones, In-vitro anticancer activity

Authors

First Name

Reham

Last Name

Ibrahim

MiddleName

-

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, University of Alexandria, Alexandria 21521, Egypt

Email

rehamsaid84@yahoo.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Seif El-Din

MiddleName

-

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt

Email

-

City

-

Orcid

-

First Name

Marwa

Last Name

Abu-Serie

MiddleName

-

Affiliation

Medical Biotechnolog Department, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, Sadat City, Egypt

Email

-

City

-

Orcid

-

First Name

Nevine

Last Name

Abd El Rahman

MiddleName

-

Affiliation

Pharmaceutical & Fermentation Industries Development Center, City of Scientifc Research and Technological Applications, Alexandria, Egypt

Email

-

City

-

Orcid

-

First Name

Maha

Last Name

El-Demellawy

MiddleName

-

Affiliation

Medical Biotechnolog Department, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, Sadat City, Egypt , Pharmaceutical & Fermentation Industries Development Center, City of Scientific Research and Technological Applications, Alexandria, Egypt

Email

-

City

-

Orcid

-

First Name

Aly

Last Name

Metwally

MiddleName

-

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt

Email

-

City

-

Orcid

-

Volume

1

Article Issue

2

Related Issue

1064

Issue Date

2017-09-01

Receive Date

2017-06-17

Publish Date

2017-09-01

Page Start

13

Page End

20

Print ISSN

2536-9857

Online ISSN

2535-2091

Article File

RPBS_Volume 1_Issue 2_Pages 13-20.pdf

PDF . 881.4kB

Link

https://rpbs.journals.ekb.eg/article_5924.html

Detail API

https://rpbs.journals.ekb.eg/service?article_code=5924

Order

3

Type

Original Article

Type Code

532

Publication Type

Journal

Publication Title

Records of Pharmaceutical and Biomedical Sciences

Publication Link

https://rpbs.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023