A high-performance liquid chromatographic method was developed for simultaneous determination of four ACE-inhibitors: captopril (CAP), perindopril erbumine (PER), moexipril hydrochloride (MOEX), and ramipril (RAM) in pharmaceutical formulations. The chromatographic separation was performed on Shim-pack cyanopropyl column with a mobile phase consisting of methanol-10mM ammonium acetate buffer (pH 6.0) in a ratio of (40: 60, v/v) at flow rate 1 ml min^-1. the analysis was performed at ambient temperature using UV detector setting at 210 nm. All ACE-inhibitors were separated within seven min. The calibration curves were linear (r ≥ 0.9994) over a concentration range from 5 to 50 µg ml^-1. the method was successfully applied to commercially available pharmaceutical preparations. The validity of the method was examined comparing the results obtained with official or published methods.