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Biodiversity of Actinomycetes and Their Secondary Metabolites: A Comprehensive Review

Article

Last updated: 03 Jan 2025

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-

Tags

Microbiology

Abstract

Background: Among prokaryotes, Actinomycetes are one of the most explored microorganism due to their capability of novel bioactive secondary metabolites production. Actinomycetes secondary metabolites are known for their role in different cellular, physiological and biological processes.
Main body: Actinomycetes are most widely distributed in natural ecosystem habitats such as soil, hypersaline soil, rhizosphere soil, freshwater, limestone, volcanic cave, marine sediments, sponges, and desert. Actinomycetes bioactive secondary metabolites most important features are that they have specific microbial producers, diverse bioactivities and unique chemical structures. Some important antibiotics produced by actinomycetes are actinomycetin, mycetin, micromonosporin and from actinomyces are lysozyme, actinomycin, streptothricin, proactinomycin and streptomycin. These antibiotics differ greatly in their structure, antimicrobial and toxicity properties. Actinomycetes secondary metabolites include spirotetronate, quinones, lactams, aminoglycosides, β-lactams, diketones, aromatic ketones, ansamycin, glycopeptides, lactones, Tetracenediones, anthracyclines, macrolides, fattiviracins, polyenes and tetracyclines, natural polycyclic polyketide.
Conclusion: This review study summarized that Actinomycetes are naturally distributed species found in diverse environments. It is assumed that actinomycetes species found in extreme conditions have the capability to produce novel bioactive secondary metabolites that remain unexplored yet.

DOI

10.21608/jabps.2022.161607.1165

Keywords

Actinomycetes, antibiotics, Biodiversity of Actinomycetes, secondary metabolites

Authors

First Name

Sadaf

Last Name

khan

MiddleName

-

Affiliation

Institute of Biotechnology and Genetic Engineering University, The University of Agriculture Peshawar, Pakistan

Email

sadafkhan11@gmail.com

City

-

Orcid

-

First Name

Shanzeba

Last Name

,

MiddleName

-

Affiliation

Institute of Biotechnology and Genetic Engineering University, The University of Agriculture Peshawar, Pakistan

Email

sareerudin121@gmail.com

City

-

Orcid

-

First Name

Aisha

Last Name

Gul

MiddleName

-

Affiliation

Institute of Biotechnology and Genetic Engineering University, The University of Agriculture Peshawar, Pakistan

Email

aishagul@gmail.com

City

-

Orcid

-

First Name

Saqlain

Last Name

Jehan

MiddleName

-

Affiliation

Institute of Biotechnology and Genetic Engineering, The University of Agriculture Peshawar, Pakistan.

Email

saqlainjehann@gmail.com

City

-

Orcid

-

First Name

Zahid

Last Name

Khan

MiddleName

-

Affiliation

Department of Zoology, University of Swabi, Khyber Pakhtunkhwa, Pakistan

Email

zahidkhan@gmail.com

City

-

Orcid

-

First Name

Javaria

Last Name

saeed

MiddleName

-

Affiliation

Institute of Industrial Biotechnology, Government college university Lahore, Pakistan

Email

javariasaeed19@gmail.com

City

-

Orcid

-

First Name

Ramiz

Last Name

Shirazi

MiddleName

Raza

Affiliation

Department of Chemistry, Government College University Faisalabad Pakistan

Email

nadiariaz186@gmail.com

City

-

Orcid

-

First Name

Abdur

Last Name

Raziq

MiddleName

-

Affiliation

Department of Bioinformatics & Biotechnology, Faculty of Life Science, Government College University Faisalabad, Pakistan.

Email

irfanmanzoorgcuf@gmail.com

City

-

Orcid

-

First Name

Muhammad

Last Name

Waseem Khan

MiddleName

-

Affiliation

Department of Biotechnology, Faculty of Life Sciences and Informatics, Balochistan University of Information Technology Engineering and Management Sciences

Email

waseemkhan@buitms.edu.pk

City

Quetta

Orcid

-

First Name

Hayat

Last Name

Ullah

MiddleName

-

Affiliation

Government College University Faisalabad

Email

hayatullah22@gcuf.edu.pk

City

Punjab

Orcid

0000-0002-9463-8528

Volume

6

Article Issue

1

Related Issue

38484

Issue Date

2023-01-01

Receive Date

2022-09-08

Publish Date

2023-01-01

Page Start

36

Page End

48

Print ISSN

2535-1869

Online ISSN

2535-2040

Article File

JABPS_Volume 6_Issue 1_Pages 36-48.pdf

PDF . 524.7kB

Link

https://jabps.journals.ekb.eg/article_276250.html

Detail API

https://jabps.journals.ekb.eg/service?article_code=276250

Order

5

Type

Review Articles

Type Code

523

Publication Type

Journal

Publication Title

Journal of advanced Biomedical and Pharmaceutical Sciences

Publication Link

https://jabps.journals.ekb.eg/

MainTitle

Biodiversity of Actinomycetes and Their Secondary Metabolites: A Comprehensive Review

Details

Type

Article

Created At

22 Jan 2023