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276249

Mechanisms of Paclitaxel-induced peripheral neuropathy

Article

Last updated: 03 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Pharmacology and Toxicology

Abstract

Peripheral neuropathy is a common adverse effect associated with the use of a group of chemotherapeutic agents including paclitaxel (PTX) which negatively affect the quality of life of cancer survivors. In addition, it is considered as a dose-limiting side effect that hinder completion of appropriate chemotherapy regimen. In spite of 27 years of research in mechanisms of PTX neuropathy, there is no approved therapy for prevention of PTX-induced peripheral neuropathy (PIPN). Thus, there is a continuous need to characterize the possible mechanisms associates with PIPN in order to find appropriate targeted therapy for this clinical problem. In this review, we summarized most of the recent findings of the cellular targets implicated in PIPN.
 

DOI

10.21608/jabps.2022.170238.1172

Keywords

Paclitaxel neuropathy, immune reaction, axonal transport, Mitochondrial dysfunction

Authors

First Name

Asmaa

Last Name

Hammad

MiddleName

-

Affiliation

Department of pharmacology and toxicology, faculty of pharmacy, Minia university, Egypt

Email

assmaaslyman@minia.edu.eg

City

-

Orcid

-

First Name

Sayed Ahmed

Last Name

Mohamed M

MiddleName

-

Affiliation

Pharmacology and Experimental Oncology Unit, National Cancer Institute, Cairo University, Egypt.

Email

sayedahmedmm@hotmail.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Khalifa

MiddleName

-

Affiliation

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, Egypt

Email

asfahmed7@gmail.com

City

-

Orcid

-

First Name

Mahmoud

Last Name

El-Daly

MiddleName

-

Affiliation

Department of Pharmacology & Toxicology, Faculty of Pharmacy, Minia University, El-Minia 61519, Egypt

Email

eldaly_m@mu.edu.eg

City

-

Orcid

0000-0001-5971-1104

Volume

6

Article Issue

1

Related Issue

38484

Issue Date

2023-01-01

Receive Date

2022-10-22

Publish Date

2023-01-01

Page Start

25

Page End

35

Print ISSN

2535-1869

Online ISSN

2535-2040

Article File

JABPS_Volume 6_Issue 1_Pages 25-35.pdf

PDF . 487.3kB

Link

https://jabps.journals.ekb.eg/article_276249.html

Detail API

https://jabps.journals.ekb.eg/service?article_code=276249

Order

4

Type

Review Articles

Type Code

523

Publication Type

Journal

Publication Title

Journal of advanced Biomedical and Pharmaceutical Sciences

Publication Link

https://jabps.journals.ekb.eg/

MainTitle

Mechanisms of Paclitaxel-induced peripheral neuropathy

Details

Type

Article

Created At

22 Jan 2023