As a result of the mistaken belief of some people that Waterpipe has some positive effects to kill some microbes. That is why we did this study. The samples Mango Flavored Moȃssel (MFM) and Peppermint Flavored Moâssel (PepFM) were obtained from Al Dandash company. They were analyzed by Headspace GC-MS. There was a great difference between the two investigated samples. The 21 identified compounds of the MFM sample were detected, which represented (88.85%) of the total compounds. The major one was 1,2-propanediol (41.40%). While, the PepFM specimen exhibited 26 identified compounds, which represented (76.84%) of the total constituents. The chief constituent was menthol (33.89%). MFM displayed 6 common compounds with PepFM; acetone, furfural, limonene, linalool, α-terpineol and carvone. The tested bacterial strains (Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa) were susceptible to growth inhibition by MFM and PepFM methanol condensates. Moreover, the tested fungus Candida albicans exhibited also growth inhibition by the two flavored methanol condensates. Finally, microbial adherence was achieved at higher concentrations of methanol condensates (above MIC). This is due to the growth inhibitory effects of methanol condensates. While, at low concentrations (sub MIC), it was found that microbial adherence increased. Consequently, these flavored Moâssel are not recommended to use them as antimicrobial agents.