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178716

Recent Strategies in Design of Antitumor and Antibacterial Fluoroquinolones

Article

Last updated: 03 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Analytical and Medicinal Chemistry

Abstract

Fluoroquinolones are known widely used synthetic antibacterial agents. Generally, there were some obstacles associated with their therapeutic use. Moreover, many research studies all over the world proved the variable biological effects of fluoroquinolones such as antituberculosis, anticancer, or even antiviral activities. The current review is focused on modifications that occurred in the fluoroquinolone scaffold for their repositioning from antibacterial into anticancer agents especially modifications at C-7 or at the carboxylic C-3 groups. In addition, it includes the recent research studies carried out to improve the potency, spectrum of activity, or pharmacokinetics of antibacterial fluoroquinolones. Hence, this review may be useful for researchers in the design and synthesis of new fluoroquinolones with improved biological activities.

DOI

10.21608/jabps.2021.68305.1124

Keywords

Fluoroquinolones, antitumor, Antibacterial, design

Authors

First Name

Mohamed

Last Name

Samir

MiddleName

-

Affiliation

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, 71524 Assiut

Email

muhammed_samir2003@yahoo.com

City

Assiut

Orcid

-

First Name

Mohammed

Last Name

Ramadan

MiddleName

-

Affiliation

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, 71524 Assiut, Egypt

Email

elbashamohammed@yahoo.com

City

Assiut

Orcid

-

First Name

Mostafa

Last Name

Hamed

MiddleName

-

Affiliation

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, 71524 Assiut, Egypt

Email

mhamed102004@yahoo.com

City

Assiut

Orcid

-

First Name

Mohamed

Last Name

Osman

MiddleName

-

Affiliation

Medicinal Chemistry Department, Faculty of Pharmacy, Minia University.

Email

abulnil@hotmail.com

City

Minia

Orcid

-

First Name

Gamal

Last Name

Abou=Rahma

MiddleName

-

Affiliation

Medicinal Chemistry Department, Faculty of Pharmacy, Minia University

Email

gamalaburahma@yahoo.com

City

-

Orcid

-

Volume

4

Article Issue

3

Related Issue

26219

Issue Date

2021-07-01

Receive Date

2021-03-28

Publish Date

2021-07-01

Page Start

134

Page End

151

Print ISSN

2535-1869

Online ISSN

2535-2040

Article File

JABPS_Volume 4_Issue 3_Pages 134-151.pdf

PDF . 1.6MB

Link

https://jabps.journals.ekb.eg/article_178716.html

Detail API

https://jabps.journals.ekb.eg/service?article_code=178716

Order

3

Type

Review Articles

Type Code

523

Publication Type

Journal

Publication Title

Journal of advanced Biomedical and Pharmaceutical Sciences

Publication Link

https://jabps.journals.ekb.eg/

MainTitle

Recent Strategies in Design of Antitumor and Antibacterial Fluoroquinolones

Details

Type

Article

Created At

22 Jan 2023