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159065

3-Cyano-2-oxa-pyridines: a promising template for diverse pharmacological activities

Article

Last updated: 23 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Analytical and Medicinal Chemistry

Abstract

Pyridines have occupied a unique place in medicinal chemistry as it is widely profound as natural products and formed the integral backbone of great number of drugs in the market. In particular, 3-cyano-2-oxa-pyridines showed diverse biological and pharmacological activities such as cardiotonic, antimicrobial, antidepressant, and anticancer activity. 3-Cyano-2-oxa-pyridine derivatives have elevated importance for modern medicinal applications especially in cancer therapy. This article shed light on the general chemical synthetic approaches of 3-cyano-2-oxa-pyridines and summarized their various biological activities and pharmacological uses. This article may be helpful in the future to direct attention towards utilization of 3-cyano-2-oxa-pyridine template in the design of new molecules with enhanced biological properties such as PIM1 kinase, tubulin polymerase and survivin inhibitors for cancer therapy or new AMPK activator for diabetes and obesity control or cardiotonic agents.

DOI

10.21608/jabps.2020.52641.1113

Keywords

cyanopyridines, PIM-1 kinase inhibitors, Survivin inhibitors, AMPK activators

Authors

First Name

Amr

Last Name

Bass

MiddleName

Kamal

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Menoufia University Menoufia, Egypt

Email

amr_ph_80@yahoo.com

City

-

Orcid

0000-0002-0588-0073

First Name

Elshimaa

Last Name

Abdelhafez

MiddleName

-

Affiliation

Associate professor at Medicinal chemistry department Minia university

Email

shimaanaguib_80@mu.edu.eg

City

-

Orcid

-

First Name

Mona

Last Name

El-Zoghbi

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Menoufia University, Menoufia, Egypt.

Email

mona_elzoghbi@yahoo.com

City

-

Orcid

-

First Name

Mamdouh

Last Name

Mohamed

MiddleName

F. A.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, 82524 Sohag, Egypt

Email

mamdouhfawzy3@yahoo.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Badr

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Menoufia University, Menoufia, Egypt

Email

mohabadr180@gmail.com

City

-

Orcid

-

First Name

Gamal El-Din

Last Name

Abuo-Rahma

MiddleName

A A

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, New Minia, Minia, Egypt.

Email

gamal.aborahama@mu.edu.eg

City

-

Orcid

-

Volume

4

Article Issue

2

Related Issue

23463

Issue Date

2021-04-01

Receive Date

2020-12-07

Publish Date

2021-04-01

Page Start

81

Page End

86

Print ISSN

2535-1869

Online ISSN

2535-2040

Article File

JABPS_Volume 4_Issue 2_Pages 81-86.pdf

PDF . 653.8kB

Link

https://jabps.journals.ekb.eg/article_159065.html

Detail API

https://jabps.journals.ekb.eg/service?article_code=159065

Order

3

Type

Review Articles

Type Code

523

Publication Type

Journal

Publication Title

Journal of advanced Biomedical and Pharmaceutical Sciences

Publication Link

https://jabps.journals.ekb.eg/

MainTitle

3-Cyano-2-oxa-pyridines: a promising template for diverse pharmacological activities

Details

Type

Article

Created At

22 Jan 2023