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79122

P53 and endoglin, two biomarkers for predicting HBV and hepatocellular carcinoma in Egyptian patients

Article

Last updated: 03 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Biochemistry

Abstract

Background: liver biopsy is considered the golden standard for the investigation of fibrosis and hepatocellular carcinoma (HCC). However, liver biopsy is costly and may lead to medical complications in some cases. Therefore, the search for non-invasive biomarkers is a good alternative.
Aim: the present study aims to analyse the interactive role of serum alpha fetoprotein (AFP), soluble endoglin and p53 in diagnosis of patients with chronic hepatitis B virus (HBV), and early stage HCC.
Patients and methods: This study included 56 patients, divided into three groups. Group I: Composed of 18 healthy controls. Group II: included 13 chronic HBV. Group III: included 25 newly diagnosed, stage II HCC. Viral markers, liver function tests, blood sugar level, kidney function tests and AFP were assessed using standard methods. Serum levels of p53 and soluble endoglin were determined using ELISA kits.
Results: Group II showed normal liver functions except for higher total protein and albumin mean levels, whereas group III revealed significantly higher ALT, AST, ALP, total and direct bilirubin. The mean AFP serum levels were significantly increased in groups II and III in relation to the control group in an ascending order. The mean value of soluble endoglin was significantly altered in group II and III compared to that of control group. Only group III showed a significant increases in p53 level compared to control group.
Conclusion: the results showed that p53 and endoglin are potential biomarkers that can help in the diagnosis of hepatocellular carcinoma when used in addition to AFP.

DOI

10.21608/jabps.2020.24533.1075

Keywords

HCC, HBV, p53, endoglin

Authors

First Name

Sultan

Last Name

Al thagfan

MiddleName

S

Affiliation

Department of clinical and hospital pharmacy, College of Pharmacy, Taibah University, Medina, Kingdom of Saudi Arabia

Email

salthagfan@gmail.com

City

-

Orcid

-

First Name

Abdel rahman

Last Name

Abdel Qawy

MiddleName

H

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt

Email

abdelrahmanhassa@yahoo.com

City

-

Orcid

-

First Name

Michael

Last Name

Fawzy

MiddleName

A

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt

Email

michaelfawzy777@yahoo.com

City

-

Orcid

-

First Name

Arwa

Last Name

Ali

MiddleName

-

Affiliation

Department of Medical oncology, South Egypt Cancer Institute, Assiut, Egypt

Email

mekky68@gmail.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Abdel-Latif

MiddleName

M.

Affiliation

Department of Clinical Pharmacy, Faculty of Pharmacy, Assiut University, 71515 Assiut, Egypt

Email

abouzied02@yahoo.com

City

-

Orcid

-

First Name

Heba

Last Name

Eltahir

MiddleName

M

Affiliation

Department of pharmacology and toxicology (biochemistry division), College of Pharmacy, Taibah University, Medina, Kingdom of Saudi Arabia

Email

heba_m.eltahir@yahoo.com

City

-

Orcid

-

First Name

Hossein

Last Name

Elbadawy

MiddleName

M

Affiliation

Department of pharmacology and toxicology, College of Pharmacy, Taibah University, Medina, Kingdom of Saudi Arabia

Email

hossein.elbadawy@hotmail.com

City

-

Orcid

-

First Name

Yaser

Last Name

Alahmadi

MiddleName

M

Affiliation

Department of clinical and hospital pharmacy, College of Pharmacy, Taibah University, Medina, Kingdom of Saudi Arabia

Email

yalahmadi45@gmail.com

City

-

Orcid

-

First Name

Omar

Last Name

Mohafz

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, 71524 Assiut, Egypt

Email

omarmohafez@yahoo.com

City

-

Orcid

-

First Name

Mekky

Last Name

Abouzied

MiddleName

M

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt, Department of pharmacology and toxicology (biochemistry division), College of Pharmacy, Taibah University, Medina, Kingdom of Saudi Arabia

Email

m_meky2001@yahoo.com

City

-

Orcid

-

First Name

Maiiada

Last Name

Nazmy

MiddleName

H

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt

Email

maiiada_nazmy@mu.edu.eg

City

Minia

Orcid

-

Volume

3

Article Issue

2

Related Issue

11874

Issue Date

2020-04-01

Receive Date

2020-02-26

Publish Date

2020-04-01

Page Start

110

Page End

115

Print ISSN

2535-1869

Online ISSN

2535-2040

Article File

JABPS_Volume 3_Issue 2_Pages 110-115.pdf

PDF . 563.2kB

Link

https://jabps.journals.ekb.eg/article_79122.html

Detail API

https://jabps.journals.ekb.eg/service?article_code=79122

Order

8

Type

Original Article

Type Code

522

Publication Type

Journal

Publication Title

Journal of advanced Biomedical and Pharmaceutical Sciences

Publication Link

https://jabps.journals.ekb.eg/

MainTitle

P53 and endoglin, two biomarkers for predicting HBV and hepatocellular carcinoma in Egyptian patients

Details

Type

Article

Created At

22 Jan 2023