70783

Formulation And Evaluation Of Buccoadhesive Films of Lidocaine Hydrochloride

Article

Last updated: 03 Jan 2025

Subjects

-

Tags

Pharmaceutics

Abstract

Buccal delivery is considered the most suitable, easy, and safest route of administration. So it can be used as an alternative route to the peroral route for the systemic administration of drugs. Oral films (OFs) are used as a unique approach, because it dissolves quickly in the mouth and directly reaches to the systemic circulation. The aim of this study is to formulate and evaluate OF of an anaethetic drug lidocaine (LH) and improve its local effect. Oral films were prepared by using chitosan and polyvinylpyrolidone. OFs were assessed for compatibility studies, surface pH, swelling properties, In-Vitro bioadhesion, mechanical properties, disintegration time, dissolution time and in- vitro drug release. It was found that actual LH content in the prepared patch was in the range of 95-105% of the claimed content. The addition of propylene glycol as a plasticizer gave good mechanical properties in concentration of 40%. The prepared oral films swelled and reached an Equilibrium state of swelling. The prepared polymeric films showed good adhesion and acceptable pH. It could be concluded that the release of LH is higher from films contain 1% chitosan. Increasing chitosan concentration to 2% resulted in decreasing the initial dissolution rate. The combination of chitosan (2%) , PVP(10%) and PG at 40% w/w gave a reasonable LH release.

DOI

10.21608/jabps.2020.21927.1066

Keywords

Lidocaine, Buccoadhesive, Film casting, tensile strength, In vitro release

Authors

First Name

Gamal

Last Name

Mahrous

MiddleName

M.

Affiliation

Department of Pharmaceutics, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Gamal

Last Name

Shazly

MiddleName

-

Affiliation

Department of Pharmaceutics, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia, Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University 71526, Assiut, Egypt

Email

gaahmed@ksu.edu.sa

City

-

Orcid

-

First Name

Diaa

Last Name

Zidan

MiddleName

Eldin

Affiliation

Department of Pharmaceutics, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Aly

Last Name

Abdel Zaher

MiddleName

A.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University 71526, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

Mona

Last Name

El-Mahdy

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University 71526, Assiut, Egypt

Email

-

City

-

Orcid

-

Volume

3

Article Issue

2

Related Issue

11874

Issue Date

2020-04-01

Receive Date

2020-01-04

Publish Date

2020-04-01

Page Start

53

Page End

59

Print ISSN

2535-1869

Online ISSN

2535-2040

Link

https://jabps.journals.ekb.eg/article_70783.html

Detail API

https://jabps.journals.ekb.eg/service?article_code=70783

Order

2

Type

Original Article

Type Code

522

Publication Type

Journal

Publication Title

Journal of advanced Biomedical and Pharmaceutical Sciences

Publication Link

https://jabps.journals.ekb.eg/

MainTitle

Formulation And Evaluation Of Buccoadhesive Films of Lidocaine Hydrochloride

Details

Type

Article

Created At

22 Jan 2023