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70782

Novel Benzimidazole/Hydrazone Derivatives as Promising Anticancer Lead Compounds: Design, Synthesis, and Molecular Docking Study

Article

Last updated: 23 Dec 2024

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Subjects

-

Tags

Analytical and Medicinal Chemistry

Abstract

A novel series of benzimidazole-hydrazone derivatives was designed and synthesized as a potential anti-cancer agents. The structure of the target compounds was assured using different spectroscopic methods such as IR , 1H NMR, 13C NMR and elemental analysis. These new compounds were examined and evaluated for their antiproliferative activities against 60 different cell lines. Combination of benzimidazole scaffold with hydrazone group exhibited promising anti-cancer activity. Compounds 3a and 3b showed significant activity against different cancer cells lines between 50-84 % of growth inhibition. A molecular modeling study for compounds 3a and 3b into VEGFR-2 active site was performed with reasonable docking scores.

DOI

10.21608/jabps.2020.21160.1064

Keywords

Benzimidazole, hydrazone, Anti-cancer, Molecular docking

Authors

First Name

Martha

Last Name

Morcoss

MiddleName

M.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Nahda University, 62513 New Beni Suef, Egypt

Email

martha.moheb@nub.edu.eg

City

-

Orcid

-

First Name

El Shimaa

Last Name

Abdelhafez

MiddleName

M. N.

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt

Email

shimaanaguib_80@mu.edu.eg

City

-

Orcid

-

First Name

Hamdy

Last Name

Abdel-Rahman

MiddleName

M.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Nahda University, 62513 New Beni Suef, Egypt, Department of Medicinal Chemistry, Faculty of Pharmacy, Assiut University, 71526 Assiut, Egypt

Email

hamdy.abdelrahman@nub.edu.eg

City

-

Orcid

-

First Name

Mohamed

Last Name

Abdel-Aziz

MiddleName

-

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt

Email

abulnil@hotmail.com

City

Minia

Orcid

-

First Name

Dalal

Last Name

Abou El-Ella

MiddleName

A.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, 11566 Abbassia, Cairo, Egypt

Email

dalal.abdelrahman@nub.edu.eg

City

cairo

Orcid

-

Volume

3

Article Issue

2

Related Issue

11874

Issue Date

2020-04-01

Receive Date

2019-12-18

Publish Date

2020-04-01

Page Start

45

Page End

52

Print ISSN

2535-1869

Online ISSN

2535-2040

Article File

JABPS_Volume 3_Issue 2_Pages 45-52.pdf

PDF . 1.4MB

Link

https://jabps.journals.ekb.eg/article_70782.html

Detail API

https://jabps.journals.ekb.eg/service?article_code=70782

Order

1

Type

Original Article

Type Code

522

Publication Type

Journal

Publication Title

Journal of advanced Biomedical and Pharmaceutical Sciences

Publication Link

https://jabps.journals.ekb.eg/

MainTitle

Novel Benzimidazole/Hydrazone Derivatives as Promising Anticancer Lead Compounds: Design, Synthesis, and Molecular Docking Study

Details

Type

Article

Created At

22 Jan 2023