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50537

Synthesized oxime and ketone derivatives of ibuprofen have higher hepatic safety profile and hepatoprotective potential against acute CCl4 - induced hepatotoxicity in rats

Article

Last updated: 03 Jan 2025

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Subjects

-

Tags

Biochemistry

Abstract

Despite previously reported high hepatic safety profile of ibuprofen (IBP), but other reports oppose its use in hepatic patients. The aim of this study is to evaluate the possible effect of IBP besides its oxime (OI) and ketone (KI) derivatives in both normal liver and in acute CCl4-induced hepatotoxicity. Sixty adult male Wistar rats were used, divided into 8 groups. Group 1: received saline water as normal control. Groups 2,3,4: treated with IBP, OI or KI respectively. Group 5: treated with CCl4 to induce hepatotoxicity. Groups 6,7,8: treated with IBP, OI or KI respectively 30 minutes before CCl4 administration. Current results showed that despite the apparent hepatotoxic effects of IBP, which were less evident in OI and KI, on normal liver that may be explained by possible immunological idiosyncrasy, they ameliorated both hepatocellular and cholestatic damage induced by CCl4, which may be attributed to their anti-inflammatory and anti-oxidant potential. OI and KI derivatives, rather than IBP, showed higher hepatic safety profile and stronger hepatoprotective potential against acute CCl4-induced hepatotoxicity, which favor their use, instead of IBP, in concurrent hepatic diseases.

DOI

10.21608/jabps.2019.15584.1053

Keywords

Ibuprofen, Oxime, Ketone, Carbon tetrachloride, Hepatotoxicity

Authors

First Name

Hend

Last Name

Abd-Elhakam

MiddleName

A.

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt

Email

dr.noda2017@gmail.com

City

-

Orcid

-

First Name

Thoraya

Last Name

El-Deeb

MiddleName

S.

Affiliation

Department of Biochemistry, Faculty of Medicine, Assiut University, 71515 Assiut, Egypt

Email

thoraya_eldeeb@yahoo.com

City

-

Orcid

-

First Name

Heba

Last Name

Abd-Ellah

MiddleName

H.

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt

Email

hebasalehdr2011@gmail.com

City

-

Orcid

-

First Name

Mai

Last Name

Shoman

MiddleName

E.

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt

Email

mai_shoman@mu.edu.eg

City

Minia

Orcid

0000-0001-6837-5093

First Name

Eman

Last Name

Beshr

MiddleName

A. M.

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt

Email

emanbeshr@yahoo.com

City

Minia

Orcid

-

First Name

Mohamed

Last Name

Abdel-Aziz

MiddleName

-

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt

Email

abulnil@hotmail.com

City

Minia

Orcid

-

First Name

Maiiada

Last Name

Nazmy

MiddleName

H.

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt

Email

mnazmy@yahoo.com

City

Minia

Orcid

-

Volume

2

Article Issue

4

Related Issue

7864

Issue Date

2019-10-01

Receive Date

2019-08-03

Publish Date

2019-10-01

Page Start

185

Page End

190

Print ISSN

2535-1869

Online ISSN

2535-2040

Article File

JABPS_Volume 2_Issue 4_Pages 185-190.pdf

PDF . 1.0MB

Link

https://jabps.journals.ekb.eg/article_50537.html

Detail API

https://jabps.journals.ekb.eg/service?article_code=50537

Order

5

Type

Original Article

Type Code

522

Publication Type

Journal

Publication Title

Journal of advanced Biomedical and Pharmaceutical Sciences

Publication Link

https://jabps.journals.ekb.eg/

MainTitle

Synthesized oxime and ketone derivatives of ibuprofen have higher hepatic safety profile and hepatoprotective potential against acute CCl4 - induced hepatotoxicity in rats

Details

Type

Article

Created At

22 Jan 2023