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44190

Recent Prospectives of Anticancer Histone Deacetylase Inhibitors

Article

Last updated: 03 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Analytical and Medicinal Chemistry

Abstract

Histone deacetylases (HDACs) are common targets for cancer therapy as they are expressed in many forms of cancers; several research studies have been introduced discussing the design of small molecules that target this abnormal epigenetic changes developed by HDACs in chromatin. In the past 10 years, HDAC inhibitors have emerged as important agents of interest in clinical trials for several types of cancers and other diseases. Due to the recent availability of a number of HDACIs into market as effective anticancer agents (like vorinostat, belinostat, panobinostat, romidepsin, chidamide and pracinostat), HDACIs are considered one of the promising targeted anticancer agents. The current review highlights the most recent chemical modifications of HDACIs including different caps, linkers and zinc binding groups and interestingly the dual acting or multi-targeted HDACIs.

DOI

10.21608/jabps.2019.14468.1051

Keywords

Anticancer, HDACIs, Hydroxamic acids, Multi-targeted HDACIs

Authors

First Name

Shymaa

Last Name

Abbass

MiddleName

A.

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt

Email

shymaaahmed9999@gmail.com

City

Minia

Orcid

-

First Name

Heba

Last Name

Hassan

MiddleName

A.

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt

Email

hebahassan2009@live.com

City

Minia

Orcid

-

First Name

Mamdouh

Last Name

Mohamed

MiddleName

F. A.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, Sohag 82524, Egypt

Email

mamdouhfawzy3@yahoo.com

City

Sohag

Orcid

-

First Name

Gamal

Last Name

Moustafa

MiddleName

A. I.

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt

Email

gamalidris@live.com

City

Minia

Orcid

-

First Name

Gamal

Last Name

Abuo-Rahma

MiddleName

El-Din A.

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt

Email

gamal.aborahma@mu.edu.eg

City

Minia

Orcid

-

Volume

2

Article Issue

4

Related Issue

7864

Issue Date

2019-10-01

Receive Date

2019-07-06

Publish Date

2019-10-01

Page Start

135

Page End

151

Print ISSN

2535-1869

Online ISSN

2535-2040

Article File

JABPS_Volume 2_Issue 4_Pages 135-151.pdf

PDF . 2.4MB

Link

https://jabps.journals.ekb.eg/article_44190.html

Detail API

https://jabps.journals.ekb.eg/service?article_code=44190

Order

2

Type

Review Articles

Type Code

523

Publication Type

Journal

Publication Title

Journal of advanced Biomedical and Pharmaceutical Sciences

Publication Link

https://jabps.journals.ekb.eg/

MainTitle

Recent Prospectives of Anticancer Histone Deacetylase Inhibitors

Details

Type

Article

Created At

22 Jan 2023