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36041

The antiinflammatory activity and LD50 of Ocimum forskolei Benth., family Lamiaceae

Article

Last updated: 23 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Pharmacognosy

Abstract

The present study aimed to determine the lethal dose {LD50} using acute toxicity models and evaluate the anti-inflammatory activity of the total ethanolic extract (TEE) and different fractions of Ocimum forskolei Benth. aerial parts (leaves and stems) following the carrageenan-induced paw edema model in rats. The results obtained revealed that the LD50 value of the TEE was 8 g/kg body weight, while the extract and different fractions showed a significant decrease in paw edema, especially the aqueous fraction treated group with a % inhibition of (40.77 %, P < 0.001) in comparison with indomethacin (55.55 %, P < 0.001) as a standard.

DOI

10.21608/jabps.2019.12973.1048

Keywords

Ocimum forskolei, Lamiaceae, Antiinflammatory, aqueous fraction

Authors

First Name

Eman

Last Name

Zahran

MiddleName

Maher

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, 61111 New Minia, Egypt

Email

emanzahran84@yahoo.com

City

Minia

Orcid

-

First Name

Hany

Last Name

khalil

MiddleName

Ezzat

Affiliation

Department of Pharmaceutical Sciences, Faculty of Clinical Pharmacy, King Faisal University, 31982 Al-Ahsa, Saudi Arabia

Email

hanyzat@yahoo.com

City

Minia

Orcid

-

First Name

Samar

Last Name

Desoukey

MiddleName

Yehia

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt

Email

drsamaryehia@gmail.com

City

Cairo

Orcid

0000-0002-4462-9674

First Name

Mostafa

Last Name

Fouad

MiddleName

Ahmed

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt

Email

m_fouad2000@yahoo.com

City

minia

Orcid

0000-0002-3909-3537

First Name

Mohamed

Last Name

Kamel

MiddleName

Salah

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, 61111 New Minia, Egypt, Department of Pharmacognosy, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt

Email

mskamel@yahoo.com

City

Minia

Orcid

-

Volume

2

Article Issue

3

Related Issue

5967

Issue Date

2019-07-01

Receive Date

2019-05-19

Publish Date

2019-07-01

Page Start

116

Page End

120

Print ISSN

2535-1869

Online ISSN

2535-2040

Article File

JABPS_Volume 2_Issue 3_Pages 116-120.pdf

PDF . 582.1kB

Link

https://jabps.journals.ekb.eg/article_36041.html

Detail API

https://jabps.journals.ekb.eg/service?article_code=36041

Order

5

Type

Short Communication.

Type Code

525

Publication Type

Journal

Publication Title

Journal of advanced Biomedical and Pharmaceutical Sciences

Publication Link

https://jabps.journals.ekb.eg/

MainTitle

The antiinflammatory activity and LD50 of Ocimum forskolei Benth., family Lamiaceae

Details

Type

Article

Created At

22 Jan 2023